Results 91 to 100 of about 1,008 (206)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, Volume 20, Issue 8, Page 2114-2128, August 2026.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Mobile Food Ordering Application using Android OS Platform

EPJ Web of Conferences, 2014
The purpose of this research is making an ordering food application based on Android with New Order, Order History, Restaurant Profile, Order Status, Tracking Order, and Setting Profile features.
Ricky Michael Yosep
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, Volume 16, Issue 8, Page 1509-1526, August 2026.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Ensuring Semantic Consistency in SysML v2 Models Through Metamodel-Driven Validation

IEEE Access
Model-Based Systems Engineering (MBSE) relies on formal models for system lifecycle management, supporting model coherence and efficient reuse of components.
Eduardo Cibrian, Jose Olivert-Iserte, Carlos Diez-Fenoy, Roy Mendieta, Juan Llorens, Jose Maria Alvarez-Rodriguez   +5 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, Volume 16, Issue 8, Page 1527-1536, August 2026.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Towards an effective approach for composition of model transformations

Frontiers in Computer Science
Model Driven Engineering (MDE) adoption in the industry suffers from many technical and non-technical problems. One of the significant technical problems lies in the difficulty of building complex transformations from the composition of small and ...
Hamza Abdelmalek, Ismaïl Khriss, Abdeslam Jakimi   +2 more
doaj   +1 more source

Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort

Arthritis &Rheumatology, Volume 78, Issue 8, Page 1710-1717, August 2026.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, and throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common. The aim of this study was to develop predictive models for vasculitis
Matthias Papo, Pauline Martinot, Renato A. Sinico, Vítor Silvestre‐Teixeira, Nils Venhoff, Maria‐Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claudia Feder, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean‐Emmanuel Kahn, Bernard Bonnotte, Cécile‐Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Raphaël Porcher, Benjamin Terrier, on behalf of the French Vasculitis Study Group and the Eosinophilic Granulomatosis with Polyangiitis European Study Group   +35 more
wiley   +1 more source

A Unified Specification Process for Graphical Domain-Specific Languages in Model-Based Systems Engineering

Systems
Rising complexity in cyber-physical systems development exposes challenges in the consistent and reusable specification of graphical domain-specific languages (DSLs).
Katharina Polanec, Simon Eschlberger, Markus Peter, David Hoffmann, Arndt Lüder   +4 more
doaj   +1 more source

Pre‐Infection COVID‐19 Vaccination and Long‐Term Cardiovascular Outcomes in Adults Without Preexisting Cardiovascular Disease: A Retrospective Cohort Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Long‐term cardiovascular complications after COVID‐19 are increasingly recognized, yet the protective effect of pre‐infection vaccination in individuals without prior cardiovascular disease (CVD) remains unclear. This study examined the association between COVID‐19 vaccination and major cardiovascular and related outcomes up to 3 ...
Abdul Qadeer, Muneeb Khawar, Michele Fouad, Samiksha Jain, Prutha Pathak, Awon Muhammad, Anu Radha Twayana, Kamel Ikbariah, Najam Gohar, Mueed Chaudhary, Elham Shenawa, Mirza Muhammad Hadeed Khawar   +11 more
wiley   +1 more source

When GUI‐Based Testing of Web Applications Meets Code Review

Software Testing, Verification and Reliability, Volume 36, Issue 5, August 2026.
Summary of our findings on practices, challenges, information needs and future improvements for code review of GUI‐based testing artefacts. ABSTRACT Code review is a well‐established practice to ensure code quality, identify potential bugs, promote knowledge sharing and maintain coding standards within a team or organization.
Andreas Bauer, Tomas Helmfridsson, Emil Alégroth, Georg‐Daniel Schwarz   +3 more
wiley   +1 more source