Results 71 to 80 of about 1,008 (206)

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Penerapan Metode Profile Matching Dalam Pengembangan Aplikasi E-Commerce Pada Penjualan Barang Elektronik

JSiI (Jurnal Sistem Informasi), 2017
Toko Sinar Makmur merupakan salah satu toko yang berbisnis dalam bidang penjualan barang elektronik, sebagai toko yang bergerak dibidang penjualan dirasa perlu adanya sebuah aplikasi online (e-commerce) untuk membantu memperluas jangkauan penjualan dan ...
Masitoh ., Akip Suhendar
doaj   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding

The FEBS Journal, EarlyView.
Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh, Charlene Y. P. Guerrero, Madelyn R. Cusick, Amanda J. Samaras, Taylor M. Stephenson, Sebastian L. Kirkpatrick, Gregory J. Matthews, Daniel J. Cavanaugh   +7 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Improving It Infrastructures Representation: A Uml Profile

, 2012
IT infrastructures are most times informally modeled. The resulting models are ambiguous to stakeholders, cannot be checked for validity, and therefore are unable to play their important role in design, deployment and maintenance activities. The main reason for such a poor state-of-the-art lies mainly in the absence of a modeling language capable of ...
Silva, L. F. da., Brito e Abreu, F., Moreira, V.   +2 more
openaire   +3 more sources

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Contractionary Effects of Devaluation and the Balance Sheet Effect in a Macroeconomic Model With Heterogeneous Firms

Metroeconomica, EarlyView.
ABSTRACT We propose a demand‐led heterogeneous firm macroeconomic model to study the impact of an exchange rate devaluation on output and financial stability. We simulate the model and find that, in the presence of foreign debt, a devaluation can have contractionary effects.
Lucca Gustafson Rodrigues, Lílian Rolim, Laura Carvalho   +2 more
wiley   +1 more source

Una adaptación del UML Testing Profile para el Testing de Software Cuántico

Memoria Investigaciones en Ingeniería
Este estudio explora cómo la Ingeniería del Software Clásico, especialmente la ingeniería dirigida por modelos en testing, puede contribuir a la mejora de la Ingeniería del Software Cuántico (Quantum Software Engineering, QSE).
Ignacio García Rodríguez de Guzmán, Moisés Rodríguez Monje, Mario Piattini Velthuis, María Teresa Merchan Quintana   +3 more
doaj   +1 more source