Results 91 to 100 of about 14,762,295 (297)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Optimism for the UN Proclamation of the Decade of Action on Nutrition: An African Perspective [PDF]

Global Health: Science and Practice, 2016
On Friday, April 1, 2016, the United Nations (UN) General Assembly proclaimed 2016 to 2025 as a decade of action on nutrition.1 Writing as an African living and working in sub-Saharan Africa, where up to 11% of gross domestic product (GDP) is lost to malnutrition2 and where malnutrition is declining rather too slowly for anyone’s liking, this ...
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ocean Literacy as a Mechanism for Change Across and Beyond the UN Ocean Decade

Ocean and Society
Understanding the complexity of human–ocean relationships has been increasingly recognized as being central to addressing the triple crises currently facing the ocean and the communities that depend on it—climate change, biodiversity loss, and social ...
Emma McKinley, Benedict McAteer, Berit Charlotte Kaae, Brice Trouillet   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Corrigendum: Ocean Science Diplomacy can Be a Game Changer to Promote the Access to Marine Technology in Latin America and the Caribbean

Frontiers in Research Metrics and Analytics, 2021
Andrei Polejack, Andrei Polejack, Luciana Fernandes Coelho, Luciana Fernandes Coelho   +3 more
doaj   +1 more source

Indigenous and local communities can boost seed supply in the UN decade on ecosystem restoration. [PDF]

Ambio, 2022
Urzedo D, Pedrini S, Vieira DLM, Sampaio AB, Souza BDF, Campos-Filho EM, Piña-Rodrigues FCM, Schmidt IB, Junqueira RGP, Dixon K.   +9 more
europepmc   +1 more source

Ocean Decade Vision 2030 White Papers – Challenge 4: Develop a Sustainable and Equitable Ocean Economy.

This draft White Paper is one of a series of ten White Papers all of which have been authored by an expert Working Group. Accompanied by a synthesis report authored by the Decade Coordination Unit, it will be discussed at the 2024 Ocean Decade Conference
Haugan, P., Gonzales-Quiros, R., Appiott, J., Hollaway, E., Heaps, L., Mokenye, J., Kostka, W.N., Solis Rivera, V., Noonan-Birch, R., DeBeauville-Scott, S., Gelcich, S., Abdul Rahman, M., Jeremie, M.-M., Jumbe, A.S., Thiele, T., James, P., Gericksky, E., Hospes, E., Harms, E., Rhodes, A., Park, G.   +20 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The 1930s: A Decade of Modern British Fiction

, 2021
With austerity biting hard and fascism on the march at home and abroad, the Britain of the 1930s grappled with many problems familiar to us today. Moving beyond the traditional focus on 'the Auden generation', this book surveys the literature of the ...

core   +2 more sources