Results 71 to 80 of about 14,762,295 (297)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Revitalizing Development Cooperation: Issues and Priorities

Asian Development Review, 1989
The idea that a global strategy for an attack on world poverty is both feasible and desirable has gathered considerable support in the postwar years. In a famous address to the United Nations (UN) General Assembly, President John F.
Manmohan Singh
doaj   +1 more source

Measuring and monitoring the quality of dying in the UN Decade of Healthy Ageing

The Lancet Healthy Longevity
WHO aims to identify metrics to monitor the quality of dying, complementing those indicators proposed under the UN Decade of Healthy Ageing. However, the proposed criteria for a good death are contentious. Needs and priorities vary between individuals and their carers, across conditions, over time, and across communities and cultures. Monitoring should
Rowan H Harwood, Jotheeswaran Amuthavalli Thiyagarajan, Afsan Bhadelia, Andrea Foebel, Catriona R Mayland, Chetna Malhotra, Deborah Blacker, Elizabeth L Sampson, Eric Andrew Finkelstein, Harmehr Sekhon, Jean Woo, Jenny T van der Steen, Julia Verne, Leon Geffen, Lieve Van den Block, Mayaline Youssef, Megan Doherty, Moise Muzigaba, Muthoni Gichu, Sarah Hopkins, Shampa Sinha, Julie Ling, Stefania Ilinca, Ritu Sadana, Matteo Cesari, Yuka Sumi, Alana Officer, Theresa Diaz, Anshu Banerjee   +28 more
openaire   +6 more sources

UN decade on ecosystem restoration 2021-2020 - what chance for success in restoring coastal ecosystems? [PDF]

, 2019
On 1 March 2019, the United Nations (UN) General Assembly (New York) declared 2021–2030 the "UN Decade on Ecosystem Restoration." This call to action has the purpose of recognizing the need to massively accelerate global restoration of degraded ...
Gillies, Christopher, Ogburn, M.B., Duarte, C.M., Lovelock, C., Claassens, L., Sheaves, M., Barletta, Mario, Nagelkerken, I., Purandare, Jemma, Gillies, Chris, Simenstad, C., Lovelock, Catherine, Gillies, C., Elliott, Michael, Wen, Colin K.-C., Ogburn, Matthew B, Wen, Colin K.C., Connolly, Rod, Nagelkerken, Ivan, Duarte, Carlos M., Simenstad, Charles, Possingham, H., Barletta, M., Mitsch, William J., Sheaves, Marcus, Waltham, N.J., Lee, Shing Yip, Ogburn, Matthew B., Wen, Colin K-C, Lee, S.Y., Waltham, Nathan J, Claassens, Louw, Mitsch, William, Buelow, Christina, Wen, C.K.-C., Mitsch, W.J., Purandare, J., Mitsch, William J, Possingham, Hugh, Connolly, Rod M., Elliott, M., Duarte, Carlos M, Buelow, C., Connolly, Rod M, Waltham, Nathan J., Connolly, R.M.   +45 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cuba's Forgotten Decade: How the 1970s Shaped the Revolution

, 2018
Introduction taken from the edited collection Cuba's Forgotten Decade: How the 1970s Shaped the Revolution; Anna Clayfield is also co-editor of this volume.Cuba's Forgotten Decade provides a comprehensive assessment of the 1970s that challenges ...
Clayfield, Anna, Story, Isabel, Kirk, Emily J.   +2 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The high seas treaty (BBNJ agreement) and planetary sustainability: why we should manage the entirety of ABNJ as a de facto multi-use marine protected area

Frontiers in Ocean Sustainability
The High Seas Treaty (BBNJ Agreement) provides a new legal framework to protect ocean ecosystems increasingly threatened as economic activities expand across Areas Beyond National Jurisdiction (ABNJ).
Adam Moolna
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source