Results 251 to 260 of about 104,266 (277)

Striatal Dysfunction in Schizophrenia and Unaffected Relatives

Biological Psychiatry, 2006
Schizophrenia has been frequently associated with impaired inhibitory control. Such control is known to involve the striatum. Here, we investigate whether impaired inhibitory control is associated with abnormal striatal activation in schizophrenia. First-degree relatives of patients were also tested to examine whether striatal abnormality is associated
Vink, Matthijs, Ramsey, Nick F, Raemaekers, Mathijs, Kahn, René S   +3 more
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Brain Activation During Antisaccades in Unaffected Relatives of Schizophrenic Patients

Biological Psychiatry, 2006
Schizophrenia patients have difficulty inhibiting automatic saccades. Many studies have failed to resolve whether healthy first-degree relatives share the same deficit. Measures of brain activity may be more sensitive than behavioral measures. In patients, the saccadic inhibition deficit has been related to impaired frontostriatal functioning.
Raemaekers, Mathijs, Ramsey, Nick F., Vink, Matthijs, Van Den Heuvel, Martin P., Kahn, Rene S.   +4 more
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Executive functioning in anorexia nervosa patients and their unaffected relatives

Psychiatry Research, 2013
Formal genetic studies suggested a substantial genetic influence for anorexia nervosa (AN), but currently results are inconsistent. The use of the neurocognitive endophenotype approach may facilitate our understanding of the AN pathophysiology. We investigated decision-making, set-shifting and planning in AN patients (n=29) and their unaffected ...
Galimberti E, Fadda E, Cavallini MC, Martoni RM, Erzegovesi S, BELLODI , LAURA   +5 more
openaire   +2 more sources

Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

Neurology, 2005
Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult ...
J P, O'Dwyer, S, O'Riordan, R, Saunders-Pullman, S B, Bressman, F, Molloy, T, Lynch, M, Hutchinson   +6 more
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Auditory P300 in patients with bipolar disorder and their unaffected relatives

Bipolar Disorders, 2008
Objectives:  There is evidence that genetic susceptibility may be shared between bipolar disorder (BD) and schizophrenia, but electrophysiological phenotypes which have been extensively used in studies of genetic susceptibility for schizophrenia remain far less explored in bipolar illness.
Schulze, K K, Hall, M H, McDonald, C, Marshall, N, Walshe, M, Murray, R M, Bramon, E   +6 more
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Decreased serotonin transporter binding in unaffected relatives of manic depressive patients

Biological Psychiatry, 1999
There are numerous reports of decreased binding to platelet serotonin transporter (5-HTT) in depression, suggesting that it might be considered a trait marker of depression. To further investigate whether reduced 5-HTT function could be an endophenotype in manic depressive illness, we looked for abnormalities of platelet 5-HTT among subjects who are ...
M, Leboyer, P, Quintin, P, Manivet, O, Varoquaux, J F, Allilaire, J M, Launay   +5 more
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Cortical–basal ganglia imbalance in schizophrenia patients and unaffected first-degree relatives

Schizophrenia Research, 2012
Structural brain changes are amongst the most robust biological alterations in schizophrenia, and their investigation in unaffected relatives is important for an assessment of the contribution of genetic factors. In this cross-sectional morphometry study we investigated whether volume changes in SZ are linked with genetic vulnerability and whether ...
V, Oertel-Knöchel, C, Knöchel, S, Matura, A, Rotarska-Jagiela, J, Magerkurth, D, Prvulovic, C, Haenschel, H, Hampel, D E J, Linden   +8 more
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Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives

Schizophrenia Research, 2018
Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-
Zhi Li, Chao Yan, Qin-yu Lv, Zheng-hui Yi, Jian-ye Zhang, Jin-hong Wang, Simon S.Y. Lui, Yi-feng Xu, Eric F.C. Cheung, Raquel E. Gur, Ruben C. Gur, Raymond C.K. Chan   +11 more
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Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives

Biological Psychiatry, 2003
There is evidence for hippocampal volume loss in schizophrenia, but the etiology of this remains unclear. The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia.Hippocampal volumes were obtained using stereological methods from magnetic resonance scans ...
Schulze, K, McDonald, C, Frangou, S, Grech, A, Walshe, M, Sharma, T, Sigmundsson, T, Taylor, M, Murray, RM, Sham, P, Toulopoulou, T   +10 more
openaire   +4 more sources