Results 251 to 260 of about 103,359 (288)

Brain Activation During Antisaccades in Unaffected Relatives of Schizophrenic Patients

Biological Psychiatry, 2006
Schizophrenia patients have difficulty inhibiting automatic saccades. Many studies have failed to resolve whether healthy first-degree relatives share the same deficit. Measures of brain activity may be more sensitive than behavioral measures. In patients, the saccadic inhibition deficit has been related to impaired frontostriatal functioning.
Raemaekers, Mathijs, Ramsey, Nick F., Vink, Matthijs, Van Den Heuvel, Martin P., Kahn, Rene S.   +4 more
openaire   +7 more sources

Orbitofrontal Dysfunction in Patients with Obsessive-Compulsive Disorder and Their Unaffected Relatives

Science, 2008
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning).
Chamberlain, Samuel R, Menzies, Lara, Hampshire, Adam, Suckling, John, Fineberg, Naomi A, del Campo, Natalia, Aitken, Mike, Craig, Kevin, Owen, Adrian M, Bullmore, Edward T, Robbins, Trevor W, Sahakian, Barbara J   +11 more
openaire   +5 more sources

Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

Psychoneuroendocrinology, 2019
Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with ...
Klara Coello, Klaus Munkholm, Flemming Nielsen, Maj Vinberg, Lars Vedel Kessing   +4 more
openaire   +6 more sources

Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives

Biological Psychiatry, 2003
There is evidence for hippocampal volume loss in schizophrenia, but the etiology of this remains unclear. The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia.Hippocampal volumes were obtained using stereological methods from magnetic resonance scans ...
Schulze, K, McDonald, C, Frangou, S, Grech, A, Walshe, M, Sharma, T, Sigmundsson, T, Taylor, M, Murray, RM, Sham, P, Toulopoulou, T   +10 more
openaire   +6 more sources

FLUCTUATING ISLET-CELL AUTOIMMUNITY IN UNAFFECTED RELATIVES OF PATIENTS WITH INSULIN-DEPENDENT DIABETES

The Lancet, 1984
Complement-fixing islet-cell antibodies (CF-ICA) were found in 20 out of 685 unaffected first-degree relatives of children with type 1 diabetes. During a 5-year follow-up, 7 of the 20 became diabetic, 1 continued to show the antibodies without any abnormality of glucose tolerance, and 12 subjects lost them without the disease developing.
K M, Spencer, A, Tarn, B M, Dean, J, Lister, G F, Bottazzo   +4 more
openaire   +4 more sources

Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia

Schizophrenia Research, 2015
Impairments in recognising negative emotions are found in individuals with first-episode and chronic schizophrenia and also in those at ultra-high risk for the illness. Whether these impairments are an endophenotype for schizophrenia is unclear. To examine the heritability of emotion recognition, the aim of this study was to examine whether facial and ...
Kelly A, Allott, Simon, Rice, Cali F, Bartholomeusz, Claudia, Klier, Monika, Schlögelhofer, Miriam R, Schäfer, G Paul, Amminger   +6 more
openaire   +4 more sources

Striatal Dysfunction in Schizophrenia and Unaffected Relatives

Biological Psychiatry, 2006
Schizophrenia has been frequently associated with impaired inhibitory control. Such control is known to involve the striatum. Here, we investigate whether impaired inhibitory control is associated with abnormal striatal activation in schizophrenia. First-degree relatives of patients were also tested to examine whether striatal abnormality is associated
Vink, Matthijs, Ramsey, Nick F, Raemaekers, Mathijs, Kahn, René S   +3 more
openaire   +2 more sources

Executive functioning in anorexia nervosa patients and their unaffected relatives

Psychiatry Research, 2013
Formal genetic studies suggested a substantial genetic influence for anorexia nervosa (AN), but currently results are inconsistent. The use of the neurocognitive endophenotype approach may facilitate our understanding of the AN pathophysiology. We investigated decision-making, set-shifting and planning in AN patients (n=29) and their unaffected ...
Galimberti E, Fadda E, Cavallini MC, Martoni RM, Erzegovesi S, BELLODI , LAURA   +5 more
openaire   +2 more sources

Sensory abnormalities in unaffected relatives in familial adult-onset dystonia

Neurology, 2005
Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult ...
J P, O'Dwyer, S, O'Riordan, R, Saunders-Pullman, S B, Bressman, F, Molloy, T, Lynch, M, Hutchinson   +6 more
openaire   +2 more sources