Results 261 to 270 of about 104,266 (277)
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Science, 2008
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning).
Chamberlain, Samuel R +11 more
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Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning).
Chamberlain, Samuel R +11 more
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Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives
Psychoneuroendocrinology, 2019Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with ...
Klara Coello +4 more
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Pituitary volume in unaffected relatives of patients with schizophrenia and bipolar disorder
Psychoneuroendocrinology, 2008Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity has been demonstrated in both schizophrenia and bipolar disorder, but the mechanisms underlying this abnormality are still unclear. Enlarged pituitary volume has been recently reported in patients with first episode psychosis and been interpreted as a consequence of an increased activation of the ...
Mondelli, Valeria +9 more
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Mismatch Negativity in Schizophrenia, Unaffected First-degree Relatives, and Healthy Controls
Journal of Psychiatric ResearchMismatch negativity (MMN) amplitude is attenuated in schizophrenia patients (SZ). However, variability in illness course among SZ samples and types of deviant stimuli used in MMN paradigms have contributed to inconsistent findings across studies. Though MMN is suggested to be impaired in schizotypy, the potential link between the two is yet to be ...
Anushree Bose +7 more
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Brain volumes in familial and non‐familial schizophrenic probands and their unaffected relatives
American Journal of Medical Genetics, 2002AbstractStructural brain abnormalities are consistently reported in schizophrenic subjects but the etiology of these abnormalities remains unclear. We tested the contribution of genetic predisposition and obstetric complications to the structural brain abnormalities found in schizophrenic probands and their relatives.
Sham, P +10 more
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Frontal alpha asymmetry in OCD patients and unaffected first-degree relatives.
Journal of Abnormal Psychology, 2017Frontal electroencephalographic alpha asymmetry as an indicator of trait approach and trait inhibition systems has previously been studied in individuals with obsessive-compulsive disorder (OCD) with mixed results. We explored frontal alpha asymmetry as a possible risk factor in OCD by investigating a large sample of OCD patients (n = 113), healthy ...
Rosa Grützmann +8 more
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Striatal volumes in affected and unaffected relatives of bipolar patients – high-risk study
Journal of Psychiatric Research, 2009Striatal volume changes reported in bipolar disorders could represent artifacts of medication or comorbid conditions, or illness related changes, either biological predispositions or consequences of illness burden. We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar
Tomas, Hajek +6 more
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White Matter Density in Patients with Schizophrenia, Bipolar Disorder and Their Unaffected Relatives
Biological Psychiatry, 2005This study sought to assess white matter density in patients and relatives with histories of bipolar disorder and/or schizophrenia.Subjects included those with schizophrenia from families affected by schizophrenia alone, those with bipolar disorder from families affected by bipolar disorder alone and those with bipolar disorder from families affected ...
Andrew M, McIntosh +5 more
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Relative fertility of unaffected siblings of the Huntington's disease families of Tasmania
Medical Journal of Australia, 1990The relative fertility of the unaffected siblings of the Huntington's disease families of Tasmania (compared with that of the general population) is calculated to be 0.87. Evidence suggests that these people resolve to restrict their family size. Antenatal testing would allow them the freedom of choice regarding family size which the general population
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Schizophrenia Research, 2015
Impairments in recognising negative emotions are found in individuals with first-episode and chronic schizophrenia and also in those at ultra-high risk for the illness. Whether these impairments are an endophenotype for schizophrenia is unclear. To examine the heritability of emotion recognition, the aim of this study was to examine whether facial and ...
Kelly A, Allott +6 more
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Impairments in recognising negative emotions are found in individuals with first-episode and chronic schizophrenia and also in those at ultra-high risk for the illness. Whether these impairments are an endophenotype for schizophrenia is unclear. To examine the heritability of emotion recognition, the aim of this study was to examine whether facial and ...
Kelly A, Allott +6 more
openaire +2 more sources