Results 61 to 70 of about 1,815 (295)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

The Contribution of Teaching Logic to Ethical Decision Making

open access: yesCommunications, 2017
Everyone makes many important decisions in one's life and these decisions are the result of one's thinking. However, in many critical situations one cannot find a solution.
Dalibor Gonda, Petr Emanovsky
doaj   +1 more source

Ambiguity of {\omega}-Languages of Turing Machines [PDF]

open access: yesLogical Methods in Computer Science, 2014
An {\omega}-language is a set of infinite words over a finite alphabet X. We consider the class of recursive {\omega}-languages, i.e. the class of {\omega}-languages accepted by Turing machines with a B\"uchi acceptance condition, which is also the class
Olivier Finkel
doaj   +1 more source

An Analytical Method for Tensor Visualization in a Plane

open access: yesMachines, 2022
The rendering of tensor glyphs is a progressive process of visualizing the vector space both in fluid dynamics and the latest medical scanning. Nowadays, the rendering accuracy is ensured by numerical methods based on interpolation of tensor functions ...
Tomáš Stejskal   +2 more
doaj   +1 more source

Unambiguous Forest Factorization

open access: yesCoRR, 2018
In this paper, we look at an unambiguous version of Simon's forest factorization theorem, a very deep result which has wide connections in algebra, logic and automata. Given a morphism $φ$ from $Σ^+$ to a finite semigroup $S$, we construct a universal, unambiguous automaton A which is "good" for $φ$.
Paul Gastin, Shankara Narayanan Krishna
openaire   +2 more sources

Universality Problem for Unambiguous VASS

open access: yesCoRR, 2020
We study languages of unambiguous VASS, that is, Vector Addition Systems with States, whose transitions read letters from a finite alphabet, and whose acceptance condition is defined by a set of final states (i.e., the coverability language). We show that the problem of universality for unambiguous VASS is ExpSpace-complete, in sheer contrast to ...
Czerwiński, Wojciech   +2 more
openaire   +4 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Regular rewriting of active XML and unambiguity [PDF]

open access: yes, 2005
We consider here the exchange of Active XML (AXML) data, i.e., XML documents where some of the data is given explicitly while other parts are given only intensionally as calls to Web services.
Tova Milo   +2 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

The effect of the multi-step perturbations on the unambiguity ratio of DO to D for different types of data integration. [PDF]

open access: yes, 2018
The effect of the multi-step perturbations on the unambiguity ratio of DO to D for different types of data integration.
Mehdi Sadeghi (63721)   +1 more
core   +1 more source

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