Results 131 to 140 of about 1,482,534 (311)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Corporate Investment and Uncertainty: An empirical analysis [PDF]

A great deal of the relevant literature mentions that one of the reasons for the 1990s recession in Japan is increasing "uncertainty." To clarify the effect of uncertainty, this study demonstrates the relationship between uncertainty of productivity ...
SHINADA Naoki
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Fault resilience in network of energy harvesters

Journal of Physics: Complexity
Energy harvesters (EH) that scavenge energy from ambient environment are gaining popularity and are used for powering low demand devices on account of their low power outputs.
Samana Pranesh, Sayan Gupta
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Poster Proceedings of the Fifth International Conference on Scalable Uncertainty Management [PDF]

, 2011
In many applications nowadays, information systems become increasingly complex, open and dynamic. They involve massive amounts of data, generally issued from different sources.
Scalable Uncertainty Management Committee, Grant, John, Benferhat, Salem, Sudkamp, Thomas   +3 more
core   +1 more source

From Registration Uncertainty to Segmentation Uncertainty

2024 IEEE International Symposium on Biomedical Imaging (ISBI)
Understanding the uncertainty inherent in deep learning-based image registration models has been an ongoing area of research. Existing methods have been developed to quantify both transformation and appearance uncertainties related to the registration process, elucidating areas where the model may exhibit ambiguity regarding the generated deformation ...
Junyu Chen 0002, Yihao Liu 0003, Shuwen Wei, Zhangxing Bian, Aaron Carass, Yong Du 0002   +5 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Playoff Uncertainty, Match Uncertainty and Attendance at Australian National Rugby League Matches [PDF]

This paper develops a new simulation-based measure of playoff uncertainty and investigates its contribution to modelling match attendance compared to other variants of playoff uncertainty in the existing literature.
Nicholas King, Rick Audas, P Dorian Owen
core