Results 61 to 70 of about 2,241,461 (338)

Uncertainty Analysis of Neutron Diffusion Eigenvalue Problem Based on Reduced-order Model

Yuanzineng kexue jishu, 2023
In order to improve the efficiency of core physical uncertainty analysis based on sampling statistics, the proper orthogonal decomposition (POD) and Galerkin projection method were combined to study the application feasibility of reduced-order model ...
In order to improve the efficiency of core physical uncertainty analysis based on sampling statistics, the proper orthogonal decomposition (POD) and Galerkin projection method were combined to study the application feasibility of reduced-order model based on POD-Galerkin method in core physical uncertainty analysis. The two-dimensional two group TWIGL benchmark question was taken as the research object, the key variation characteristics of the core flux distribution were extracted under the finite perturbation of the group constants of each material region, and the full-order neutron diffusion problem was projected on the variation characteristics to establish a reduced-order neutron diffusion model. The reduced-order model was used to replace the full-order model to carry out the uncertainty analysis of the group constants of the material region. The results show that the bias of the mathematical expectation of keff calculated by reduced-order and full-order models is close to 1 pcm. In addition, compared with the calculation time required for uncertainty analysis of full-order model, the analysis time of reduced-order model (including the calculation time of the full-order model required for the construction of reduced-order model) is only 11.48%, which greatly improves the efficiency of uncertainty analysis. The biases of mathematical expectation of keff calculated by reduced-order and full-order models based on Latin hypercube sampling and simple random sampling are less than 8 pcm, and under the same sample size, the bias from the Latin hypercube sampling result is smaller. From the TWIGL benchmark test results, under the same sample size, Latin hypercube sampling method is more recommended for POD-Galerkin reduced-order model.
doaj  

Covid-Induced Economic Uncertainty

, 2020
Assessing the economic impact of the COVID-19 pandemic is essential for policymakers, but challenging because the crisis has unfolded with extreme speed.
S. Baker, N. Bloom, Steven J Davis, S. Terry   +3 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Collaboration Skills and Puzzles: Development of a Performance-Based Assessment—Results from 12 Primary Schools in Greece

Education Sciences
Collaboration skills are essential for the effectiveness and efficiency of collective efforts in both professional and personal contexts. However, their complex and intertwined nature poses challenges in both defining and assessing them.
Emmanouil A. Demetroulis, Ilias Papadogiannis, Manolis Wallace, Vassilis Poulopoulos, Anastasios Theodoropoulos, Nikos Vasilopoulos, Angeliki Antoniou, Fotini Dasakli   +7 more
doaj   +1 more source

A fuzzy multi-objective model and application for the discrete dynamic temporary facilities location planning problem

Journal of Civil Engineering and Management, 2016
The location of temporary facilities on construction sites is essential to the enhancement of productivity and safety, but it is complex due to the unique issues associated with construction.
Jiuping Xu, Qiurui Liu, Xiao Lei
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Region versus query based instance segmentation models: application to the estimation of aggregated TiO2 particles size distribution measured by SEM

Machine Learning: Science and Technology
Instance segmentation model performances is commonly evaluated through challenges using toy datasets such as CIFAR and ImageNet. Although, it is necessary to help improving state-of-the-art models, it remains far from critical industrial application ...
Paul Monchot, Loïc Coquelin, Nicolas Fischer   +2 more
doaj   +1 more source

Gaming for the Education of Biology in High Schools

Encyclopedia
Game-based learning refers to an educational approach where games (digital or analogue) are used in order to engage students in interactive and immersive experiences designed to teach specific concepts, skills or subjects.
Marina Lantzouni, Vassilis Poulopoulos, Manolis Wallace   +2 more
doaj   +1 more source

Applying bi-random MODM model to navigation coordinated scheduling: a case study of Three Gorges Project

Transport, 2013
The aim of this paper is to deal with the optimal navigation coordinated scheduling (NCS) problem in ship transportation of the Three Gorges Project in China, i.e. the Three Gorges Dam and the Gezhouba Dam. The NCS includes operational scheduling for two
Jiuping Xu, Zhe Zhang, Vijay S. Mookerjee   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source