Results 51 to 60 of about 868,219 (267)

Reassessing flood frequency for the Sussex Ouse, Lewes: the inclusion of historical flood information since AD 1650 [PDF]

Natural Hazards and Earth System Sciences, 2014
The application of historical flood information as a tool for augmenting instrumental flood data is increasingly recognised as a valuable tool. Most previous studies have focused on large catchments with historic settlements, this paper applies the ...
N. Macdonald, T. R. Kjeldsen, I. Prosdocimi, H. Sangster   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Collaboration Skills and Puzzles: Development of a Performance-Based Assessment—Results from 12 Primary Schools in Greece

Education Sciences
Collaboration skills are essential for the effectiveness and efficiency of collective efforts in both professional and personal contexts. However, their complex and intertwined nature poses challenges in both defining and assessing them.
Emmanouil A. Demetroulis, Ilias Papadogiannis, Manolis Wallace, Vassilis Poulopoulos, Anastasios Theodoropoulos, Nikos Vasilopoulos, Angeliki Antoniou, Fotini Dasakli   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

COMPONENTS OF UNCERTAINTY

International Economic Review, 2017
AbstractUncertainty is acknowledged to be a source of economic fluctuations. But, does the type of uncertainty matter for the economy's response to an uncertainty shock? This article offers a novel identification strategy to disentangle different types of uncertainty.
openaire   +6 more sources

Region versus query based instance segmentation models: application to the estimation of aggregated TiO2 particles size distribution measured by SEM

Machine Learning: Science and Technology
Instance segmentation model performances is commonly evaluated through challenges using toy datasets such as CIFAR and ImageNet. Although, it is necessary to help improving state-of-the-art models, it remains far from critical industrial application ...
Paul Monchot, Loïc Coquelin, Nicolas Fischer   +2 more
doaj   +1 more source

Gaming for the Education of Biology in High Schools

Encyclopedia
Game-based learning refers to an educational approach where games (digital or analogue) are used in order to engage students in interactive and immersive experiences designed to teach specific concepts, skills or subjects.
Marina Lantzouni, Vassilis Poulopoulos, Manolis Wallace   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source