Results 61 to 70 of about 868,219 (267)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Educational Data Mining: A Foundational Overview
EncyclopediaEducational data mining (EDM) is a novel scientific area that focuses on developing and applying methods to analyze datasets generated within educational settings. This paper outlines the evolution, significance, and applications of EDM.
Ilias Papadogiannis +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
PLOS Biology, 2019 The number of the distinct tactile percepts exceeds the number of receptor types in the skin, signifying that perception cannot be explained by a one-to-one mapping from a single receptor channel to a corresponding percept. The abundance of touch experiences results from multiplexing (the coexistence of multiple codes within a single channel ...
openaire +4 more sources
Journal of Civil Engineering and Management, 2016 The location of temporary facilities on construction sites is essential to the enhancement of productivity and safety, but it is complex due to the unique issues associated with construction.
Jiuping Xu, Qiurui Liu, Xiao Lei
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Uncertainty Analysis of Neutron Diffusion Eigenvalue Problem Based on Reduced-order Model
Yuanzineng kexue jishu, 2023 In order to improve the efficiency of core physical uncertainty analysis based on sampling statistics, the proper orthogonal decomposition (POD) and Galerkin projection method were combined to study the application feasibility of reduced-order model ...
In order to improve the efficiency of core physical uncertainty analysis based on sampling statistics, the proper orthogonal decomposition (POD) and Galerkin projection method were combined to study the application feasibility of reduced-order model based on POD-Galerkin method in core physical uncertainty analysis. The two-dimensional two group TWIGL benchmark question was taken as the research object, the key variation characteristics of the core flux distribution were extracted under the finite perturbation of the group constants of each material region, and the full-order neutron diffusion problem was projected on the variation characteristics to establish a reduced-order neutron diffusion model. The reduced-order model was used to replace the full-order model to carry out the uncertainty analysis of the group constants of the material region. The results show that the bias of the mathematical expectation of keff calculated by reduced-order and full-order models is close to 1 pcm. In addition, compared with the calculation time required for uncertainty analysis of full-order model, the analysis time of reduced-order model (including the calculation time of the full-order model required for the construction of reduced-order model) is only 11.48%, which greatly improves the efficiency of uncertainty analysis. The biases of mathematical expectation of keff calculated by reduced-order and full-order models based on Latin hypercube sampling and simple random sampling are less than 8 pcm, and under the same sample size, the bias from the Latin hypercube sampling result is smaller. From the TWIGL benchmark test results, under the same sample size, Latin hypercube sampling method is more recommended for POD-Galerkin reduced-order model.
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source