Results 71 to 80 of about 3,292,975 (323)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Extremely Efficient Design of Organic Thin Film Solar Cells via Learning-Based Optimization
Energies, 2017 Design of efficient thin film photovoltaic (PV) cells require optical power absorption to be computed inside a nano-scale structure of photovoltaics, dielectric and plasmonic materials.
Mine Kaya, Shima Hajimirza
doaj +1 more source
Metrology and Measurement Systems, 2020 In the framework of non-destructive evaluation (NDE), an accurate and precise characterization of defects is fundamental. This paper proposes a novel method for characterization of partial detachment of thermal barrier coatings from metallic surfaces ...
Giuseppe Dinardo +3 more
doaj +1 more source
, 1982 An evaluation is made of the suitability of analytical and statistical sampling methods for making uncertainty analyses. The adjoint method is found to be well-suited for obtaining sensitivity coefficients for computer programs involving large numbers of equations and input parameters. For this purpose the Latin Hypercube Sampling method is found to be
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Cogent Food & Agriculture, 2019 As tea (Camellia sinensis L.) yield strongly determined by local environmental conditions, thus assessing the potential impact of the seasonal and inter-annual climate variability on regional crop yield has become crucial.
Esack Edwin Raj +2 more
doaj +1 more source
Robust limit analysis theory for computing worst-case limit loads under\n uncertainties [PDF]
, 2022 Jérémy Bleyer, Vincent Leclère
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source