Results 71 to 80 of about 3,693,066 (305)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effective Data Augmentation for Active Sonar Classification Using Attention-Based Complementary Learning With Uncertainty Measure

IEEE Access
We enhance the performance of active sonar classification by integrating a validated attention-based complementary learning model (ABCL) with an active learning (AL) framework, following modifications to adapt the model for AL.
Youngsang Hwang, Geunhwan Kim, Wooyoung Hong, Youngmin Choo   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Feeling of Uncertainty Intensifies Affective Reactions [PDF]

, 2009
Uncertainty has been defined as a lack of information about an event and has been characterized as an aversive state that people are motivated to reduce.
Bar-Anan, Yoav, Gilbert, Daniel, Wilson, Timothy D.   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Uncertainty, joint uncertainty, and the quantum uncertainty principle

New Journal of Physics, 2016
Historically, the element of uncertainty in quantum mechanics has been expressed through mathematical identities called uncertainty relations, a great many of which continue to be discovered.
Varun Narasimhachar, Alireza Poostindouz, Gilad Gour   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

"Irreversible Investment and Knightian Uncertainty" [PDF]

When firms decide about irreversible investment, they may not have perfect confidence about their perceived probability measure describing future uncertainty.
Hiroyuki Ozaki, Kiyohiko G. Nishimura
core  

Macroeconomic Uncertainty: A New Measure for Italy [PDF]

, 2022
openThis thesis aims to create an alternative measure of time-varying macroeconomic uncertainty for Italy, to the commonly used proxies, and to analyse the role it plays in macroeconomic fluctuations.
SINGH, SUKHANJEET
core  

Uncertainty measures for evidential reasoning II: A new measure of total uncertainty

International Journal of Approximate Reasoning, 1993
In Part I [\textit{N. Pal}, \textit{J. Bezdek} and \textit{R. Hemasinha}, Int. J. Approx. Reasoning 7, No. 3/4, 165-183 (1992; Zbl 0769.68112)] we discussed limitations of two measures of global (non-fuzzy) uncertainty of \textit{M. Lamata} and \textit{S. Moral} [Measures of entropy in the theory of evidence, Trab. Estad. 3, No.
Nikhil R. Pal, James C. Bezdek, Rohan Hemasinha   +2 more
openaire   +3 more sources