Results 81 to 90 of about 2,076,153 (275)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

CUB models: a preliminary fuzzy approach to heterogeneity [PDF]

open access: yes, 2016
In line with the increasing attention paid to deal with uncertainty in ordinal data models, we propose to combine Fuzzy models with \cub models within questionnaire analysis.
Di Nardo, E., Simone, R.
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

The evaluation of potential for the exploration and development of coalbed methane resources based on an improved uncertainty measure optimization model

open access: yesEnergy Exploration & Exploitation, 2019
The recognition criteria of credible degree in uncertainty measure theory are improved based on the concept of distance discriminant and used to evaluate the potential for exploration and development of coalbed methane.
Jie Fang, Hujun He, Le An, Gang Jin
doaj   +1 more source

Complex Fermatean Neutrosophic Sets and their Applications in Decision Making [PDF]

open access: yesNeutrosophic Sets and Systems
Complex Neutrosophic Sets have emerged as a groundbreaking paradigm for handling uncertainty in complex-valued variables. By defining truth, indeterminacy, and falsity membership functions within the unit circle of the complex plane, this innovative ...
Vijaya V, Said Broumi , Manikandan H
doaj   +1 more source

"Irreversible Investment and Knightian Uncertainty" [PDF]

open access: yes
When firms decide about irreversible investment, they may not have perfect confidence about their perceived probability measure describing future uncertainty.
Hiroyuki Ozaki, Kiyohiko G. Nishimura
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Seeking certainty about Intolerance of Uncertainty: Addressing old and new issues through the Intolerance of Uncertainty Scale-Revised.

open access: yesPLoS ONE, 2019
Intolerance of Uncertainty is a trans-diagnostic process that spans a range of emotional disorders and it is usually measured through the Intolerance of Uncertainty Scale-12.
Gioia Bottesi   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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