Results 1 to 10 of about 35,685 (233)

Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria [PDF]

Malaria Journal, 2008
Background There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of isolates from patients with different clinical outcomes.
Looareesuwan Sornchai, Krusood Srivicha, Tangpukdee Noppadon, Iwagami Moritoshi, Susomboon Pannapa, Kano Shigeyuki   +5 more
doaj   +3 more sources

Haptoglobin gene diversity and incidence of uncomplicated malaria among children in Iganga, Uganda [PDF]

Malaria Journal, 2020
Background Haptoglobin (Hp) is an acute phase protein that takes part in systemic regulation of haem during Plasmodium falciparum infections. Numerous genotypes of haptoglobin have been reported in malaria endemic populations.
Catherine N. Lwanira, Fred Kironde, Göte Swedberg   +2 more
doaj   +2 more sources

The impact of the RTS,S malaria vaccine on uncomplicated malaria: evidence from the phase IV study districts, Upper East Region, Ghana, 2020–2022 [PDF]

Malaria Journal
Background The RTS,S malaria vaccine has been prequalified for use in endemic settings prioritizing areas with moderate to high disease transmission. The impact of a vaccine at the population level may differ from observations during clinical trial due ...
Michael Rockson Adjei, Rafiq Okine, Peter Ofori Tweneboah, Janet Vanessa Baafi, Nana Akua Afriyie, Emmanuel Akwoulo Agyigewe Teviu, Josephat Ana-Imwine Nyuzaghl, Emmanuel Kofi Dzotsi, Sally-Ann Ohene, Martin Peter Grobusch   +9 more
doaj   +2 more sources

The role of immune-inflammatory markers in children with complicated and uncomplicated malaria in Enugu, Nigeria [PDF]

BMC Immunology
Background There is currently insufficient data regarding immune parameters and relationship with severity of malaria infection in Enugu, Nigeria where the economic and social costs of the disease and its management are extremely high.
Angela Ogechukwu Ugwu, Rebecca Chinyelu Chukwuanukwu, Friday Alfred Ehiaghe, Emmanuel Onyebuchi Ugwu   +3 more
doaj   +2 more sources

Liver Injury in Uncomplicated Malaria is an Overlooked Phenomenon: An Observational StudyResearch in context [PDF]

EBioMedicine, 2018
Background: Liver injury is a known feature of severe malaria, but is only incidentally investigated in uncomplicated disease. In such cases, drug-induced hepatotoxicity is often thought to be the primary cause of the observed liver injury, and this can ...
Isaie J. Reuling, Gerdie M. de Jong, Xi Zen Yap, Muhammad Asghar, Jona Walk, Lisanne A. van de Schans, Rob Koelewijn, Anna Färnert, Quirijn de Mast, Andre J. van der Ven, Teun Bousema, Jaap J. van Hellemond, Perry J.J. van Genderen, Robert W. Sauerwein   +13 more
doaj   +2 more sources

Severe childhood malaria syndromes defined by plasma proteome profiles [PDF]

, 2012
BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood.
A Hodgetts, Adebola E. Orimadegun, AE Orimadegun, AK Rowe, AL Conroy, Barry K. Ely, Biobele J. Brown, C Wu, D Agranoff, Delmiro Fernandez-Reyes, Dimitrios Athanasakis, FE Lovegrove, Felix O. Akinbami, Florence Burté, Francesca Battaglia, Francis Akinkunmi, FX Wu, G Sandhu, J Amzat, J Bryce, K Marsh, Kevin KA. Tetteh, Kikelomo Osinusi, LK Erdman, MC Papadopoulos, Nathaniel K. Afolabi, Olayinka Kowobari, Olugbemiro Sodeinde, RT Pang, RW Snow, S Rojas-Galeano, Samuel Omokhodion, SI Hay, SI Hay, SJ Ceesay, Wasiu A. Ajetunmobi, Wuraola A. Shokunbi   +36 more
core   +25 more sources

Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis

Tropical Medicine and Infectious Disease, 2022
Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its role in acute and severe malaria is largely unknown. As a result, this study used a meta-analysis approach to investigate the difference in TGF-β levels between ...
Kwuntida Uthaisar Kotepui, Pattamaporn Kwankaew, Frederick Ramirez Masangkay, Aongart Mahittikorn, Manas Kotepui   +4 more
doaj   +1 more source

C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

Scientific Reports, 2021
This study investigated whether C-reactive protein (CRP) can be used as a marker for the early detection and monitoring of malaria severity. Potentially relevant studies were searched in Medline (PubMed), Scopus, and Web of Science.
Polrat Wilairatana, Praphassorn Mahannop, Thanita Tussato, I-mee Hayeedoloh, Rachasak Boonhok, Wiyada Kwanhian Klangbud, Wanida Mala, Kwuntida Uthaisar Kotepui, Manas Kotepui   +8 more
doaj   +1 more source

Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. [PDF]

PLoS ONE, 2018
BACKGROUND:Evidence for association between sickle cell and alpha thalassemia trait and severe malaria is compelling. However, for these polymorphisms associations with uncomplicated malaria, and for G6PD deficiency associations with uncomplicated and ...
Arthur Mpimbaza, Andrew Walakira, Grace Ndeezi, Anne Katahoire, Charles Karamagi, Samuel L Nsobya, Stephen Tukwasibwe, Victor Asua, Philip J Rosenthal   +8 more
doaj   +1 more source

Increased interferon-γ levels and risk of severe malaria: a meta-analysis

Scientific Reports, 2022
Interferon (IFN)-γ contributes to the pathogenesis of severe malaria; however, its mechanism remains unclear. Herein, differences in IFN-γ levels between patients with severe and uncomplicated malaria were evaluated using qualitative and quantitative ...
Aongart Mahittikorn, Wanida Mala, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui, Polrat Wilairatana, Manas Kotepui   +5 more
doaj   +1 more source