Results 51 to 60 of about 184,541 (267)

Highly Accurate and Efficient Time Integration Methods with Unconditional Stability and Flexible Numerical Dissipation

open access: yesMathematics, 2023
This paper constructs highly accurate and efficient time integration methods for the solution of transient problems. The motion equations of transient problems can be described by the first-order ordinary differential equations, in which the right-hand ...
Yi Ji, Yufeng Xing
doaj   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter   +17 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Longtime behavior of a semi-implicit scheme for Caginalp phase-field model

open access: yesResults in Applied Mathematics, 2021
We present a semi-implicit scheme for the Caginalp phase-field model. The scheme is a combination of implicit Euler scheme together with Eyre’s decomposition.
Mouhamadou Samsidy Goudiaby   +1 more
doaj   +1 more source

A fully semi-Lagrangian discretization for the 2D Navier--Stokes equations in the vorticity--streamfunction formulation

open access: yes, 2017
A numerical method for the two-dimensional, incompressible Navier--Stokes equations in vorticity--streamfunction form is proposed, which employs semi-Lagrangian discretizations for both the advection and diffusion terms, thus achieving unconditional ...
Bonaventura, Luca   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

A Second-Order Accurate Numerical Approximation for a Two-Sided Space-Fractional Diffusion Equation

open access: yesMathematics, 2023
In this paper, we investigate a practical numerical method for solving a one-dimensional two-sided space-fractional diffusion equation with variable coefficients in a finite domain, which is based on the classical Crank-Nicolson (CN) method combined with
Taohua Liu   +3 more
doaj   +1 more source

Conditional stability of unstable viscous shock waves in compressible gas dynamics and MHD

open access: yes, 2009
Extending our previous work in the strictly parabolic case, we show that a linearly unstable Lax-type viscous shock solution of a general quasilinear hyperbolic--parabolic system of conservation laws possesses a translation-invariant center stable ...
A. Azevedo   +25 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

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