Results 51 to 60 of about 8,382 (217)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Maximum norm error estimates of fourth-order compact difference scheme for the nonlinear Schrödinger equation involving a quintic term

Journal of Inequalities and Applications, 2018
A compact finite difference (CFD) scheme is presented for the nonlinear Schrödinger equation involving a quintic term. The two discrete conservative laws are obtained.
Hanqing Hu, Hanzhang Hu
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Solving a System of 2D Burger\'s Equations using Semi-Lagrangian Finite Difference Schemes

پژوهش‌های ریاضی, 2020
Introduction Following and generalizing the excellent work of Wang et ‎al. ‎[26], ‎we extract here some new scheme‎s, ‎based on the‎ ‎semi-Lagrangian discretization‎, ‎the modified equation theory‎, ‎and‎ ‎the local one-dimensional (LOD) scheme for ...
Reza Mokhtari, Elham Feizollahi
doaj  

A New Numerical Approximation Method for Two-Dimensional Wave Equation with Neumann Damped Boundary

Complexity, 2020
In this paper, a fully discretized finite difference scheme is derived for two-dimensional wave equation with damped Neumann boundary condition. By discrete energy method, the proposed difference scheme is proven to be of second-order convergence and of ...
Jiankang Liu, Suying Zhang
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A New Model Dimension Reduction Technique Based on Finite Volume Element and Proper Orthogonal Decomposition for Solving the 2D Hyperbolic Equation

Axioms
This article mainly researches the model dimension reduction in the finite volume element (FVE) method based on proper orthogonal decomposition (POD) for the two-dimensional (2D) hyperbolic equation.
Yuejie Li, Jing Yang, Zhendong Luo
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Compact Difference Scheme for Solving Fractional Neutral Parabolic Differential Equation with Proportional Delay

Journal of Function Spaces, 2017
A linearized compact finite difference scheme is constructed for solving the fractional neutral parabolic differential equation with proportional delay. By the energy method, the unconditional stability of the scheme is proved, and the convergence order ...
Wei Gu, Yanli Zhou, Xiangyu Ge
doaj   +1 more source