Results 51 to 60 of about 66,549 (281)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

A new spline in compression method of order four in space and two in time based on half-step grid points for the solution of the system of 1D quasi-linear hyperbolic partial differential equations

Advances in Difference Equations, 2017
In this paper, we propose a new three-level implicit method based on a half-step spline in compression method of order two in time and order four in space for the solution of one-space dimensional quasi-linear hyperbolic partial differential equation of ...
RK Mohanty, Gunjan Khurana
doaj   +1 more source

An Unconditionally Stable Method for Solving the Acoustic Wave Equation [PDF]

Mathematical Problems in Engineering, 2015
An unconditionally stable method for solving the time-domain acoustic wave equation using Associated Hermit orthogonal functions is proposed. The second-order time derivatives in acoustic wave equation are expanded by these orthogonal basis functions.
Fu, Zhi-Kai, Shi, Li-Hua, Huang, Zheng-Yu, Fu, Shang-Chen   +3 more
openaire   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Fourier Stability Analysis of Two Finite Element Schemes for Reaction-Diffusion System with Fast Reversible Reaction [PDF]

Al-Rafidain Journal of Computer Sciences and Mathematics, 2013
In this paper, the stability analysis is performed on two Galerkin finite element schemes for solving reaction-diffusion system with fast reversible reaction.
Ann Jalal, Mohammed Al-Amr
doaj   +1 more source

Unconditionally Energy Stable DG Schemes for the Swift–Hohenberg Equation [PDF]

Journal of Scientific Computing, 2019
The Swift-Hohenberg equation as a central nonlinear model in modern physics has a gradient flow structure. Here we introduce fully discrete discontinuous Galerkin (DG) schemes for a class of fourth order gradient flow problems, including the nonlinear Swift-Hohenberg equation, to produce free-energy-decaying discrete solutions, irrespective of the time
Hailiang Liu, Peimeng Yin
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

A Parallel Algorithm for Solving the Advection Equation with a Retarded Argument [PDF]

, 2015
We describe a parallel implementation of a difference scheme for the advection equation with time delay on a hybrid architecture computation system. The difference scheme has the second order in space and the first order in time and is unconditionally ...
Iumanova, I. F., Sagoyan, A. A., Solodushkin, S. I.   +2 more
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