Results 71 to 80 of about 438,581 (261)

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

A re-formulation of extended subloading surface model for cyclic plasticity within small strain framework: hyperelastic-based formulation and fully implicit return-mapping scheme

Nihon Kikai Gakkai ronbunshu, 2016
This paper presents a re-formulation of the extended subloading surface model within the ‘unconventional plasticity’ concept applicable to cyclic loadings. The small strain theory is adopted in the model formulation.
Takuya IGUCHI, Yuki YAMAKAWA, Kiyohiro IKEDA   +2 more
doaj   +1 more source

Dietary Flavonoids Interaction with CREB-BDNF Pathway: An 
Unconventional Approach for Comprehensive Management of Epilepsy

Current Neuropharmacology, 2019
cAMP response element binding protein (CREB) is a key transcriptional regulator that regulates the transcription of genes related with neuronal differentiation, synaptic plasticity, learning and memory. Brain derived neurotrophic factor (BDNF), is a CREB
Pallavi Sharma, Amit Kumar, Damanpreet Singh   +2 more
semanticscholar   +1 more source

Photocatalytic Recovery of Aromatic Chemicals from Waste Plastics

Advanced Science, EarlyView.
This Review summarizes recent advances in the photocatalytic recovery of aromatic chemicals from plastic waste, with emphasis on fundamental mechanism, representative catalytic systems, and future challenges and development directions, which is expected to provide in‐depth and valuable insights and references into the key role of sustainable catalysis ...
Lizhen Liu, Jutarat Jitrada, Jun Huang
wiley   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Unconventional NMDA Receptor Signaling

Journal of Neuroscience, 2017
In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+ to signal coincidence detection in Hebbian plasticity.
K. Dore, Ivar S. Stein, Jennifer A. Brock, Jennifer A. Brock, P. Castillo, K. Zito, P. J. Sjöström   +6 more
semanticscholar   +1 more source

Comparative analysis and modelling of newly developed and unconventional processesof plastic forming of toothed gear elements

Archives of Metallurgy and Materials, 2019
The article reports the results of a comparative analysis made for three novel unconventional gear wheel forging processes based on the authors’ patented [5,6,21] plastic forming methods developed chiefly for the purposes of extruding hollow products as well as valves and pins.
J. Michalczyk, S. Wiewiórowska, Z. Muskalski   +2 more
openaire   +2 more sources

From Flexible to Conformable Pressure Sensors: Mechanisms, Materials, and Biomedical Applications

Advanced Electronic Materials, EarlyView.
This review highlights recent progress, challenges and future opportunities in pressure sensing for advanced biomedical applications. We summarize key transduction mechanisms and emerging material strategies, discuss representative wearable and implantable applications for continuous physiological monitoring and provide a focused perspective on barrier
Rishabh B. Mishra, Andrea Ottomaniello, Virgilio Mattoli   +2 more
wiley   +1 more source

Unconventional PDZ Recognition Revealed in α7nAChR-PICK1 Complexes

ACS Chemical Neuroscience
PDZ domains are modular domains that conventionally bind to C terminal or internal motifs of target proteins to control cellular functions through the regulation of protein complex assembly.
V. Bondarenko, Qiang Chen, T. Tillman, Yan Xu, Pei Tang   +4 more
semanticscholar   +1 more source

Advancing Fruit Bioimpedance Monitoring With Sustainable, Soft, And Bio‐Based Electrodes Beyond ECG

Advanced Electronic Materials, EarlyView.
Electrical impedance spectroscopy enables non‐destructive fruit quality monitoring, but conventional ECG and needle electrodes compromise signal stability, fruit physiology, and sustainability. This perspective highlights the transition toward soft, biocompatible, and biodegradable electrode interfaces based on natural substrates, bio‐derived ...
Sundus Riaz, Ahmed Rasheed, Angelo Zanella, Almudena Rivadeneyra, Paolo Lugli, Luisa Petti, Pietro Ibba   +6 more
wiley   +1 more source