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Undenatured type II collagen and its role in improving osteoarthritis
Ageing Research Reviews, 2023Osteoarthritis (OA) is a degenerative joint disease, affecting 32.5 million US adults or 242 million people worldwide. There is no cure for OA. Many animal and clinical trials showed that oral administration of undenatured type II collagen could significantly reduce the incidence of OA or alleviate the symptoms of articular cartilage.
Jianping Wu, Lin Zheng, Mouming Zhao
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Safety and toxicological evaluation of undenatured type II collagen
Toxicology Mechanisms and Methods, 2010Previous research has shown that undenatured type II collagen is effective in the treatment of arthritis. The present study evaluated the broad-spectrum safety of UC-II by a variety of toxicological assays including acute oral, acute dermal, primary dermal irritation, and primary eye irritation toxicity.
Francis C Lau +2 more
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Undenatured type II collagen in the treatment of osteoarthritis [PDF]
Orvosi hetilap, 2021 Összefoglaló. Az arthrosis az ízületeket alkotó porc, csont és a környező lágy részek leépülésével járó betegség. A betegség jelentős fájdalommal jár, progresszív, az ízület strukturális átalakulását és ennek következtében jelentős funkcióvesztést és életminőség-romlást okoz.
Gábor Sütő, Sütő, Gábor
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Water-Soluble Undenatured Type II Collagen Ameliorates Collagen-Induced Arthritis in Mice
Journal of Medicinal Food, 2013Earlier studies have reported the efficacy of type II collagen (C II) in treating rheumatoid arthritis (RA). However, a few studies have investigated the ability of the antigenic collagen to induce oral tolerance, which is defined as active nonresponse to an orally administered antigen.
Takahisa Nakane +2 more
exaly +3 more sources
Food Chemistry, 2023
This study aimed to investigate the effects of dynamic high-pressure homogenization (DHPH), dynamic high-pressure microfluidization (DHPM), and wet media milling (WMM) processes on the particle size, microstructure, triple helix structure, wettability and suspension stability of insoluble undenatured type II collagen (IUC-II).
Like Mao, Jinfang Liu, Yanxiang Gao
exaly +3 more sources
This study aimed to investigate the effects of dynamic high-pressure homogenization (DHPH), dynamic high-pressure microfluidization (DHPM), and wet media milling (WMM) processes on the particle size, microstructure, triple helix structure, wettability and suspension stability of insoluble undenatured type II collagen (IUC-II).
Like Mao, Jinfang Liu, Yanxiang Gao
exaly +3 more sources
Osteoarthritis and Cartilage, 2017 ObjectiveThe aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA).MethodsTwenty male rats were subjected to ...
C M Bagi, N E Lane
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Points of undenatured type II collagen application in musculoskeletal pain syndromes treatment
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022The dominant collagen of the cartilaginous matrix in adults is type II collagen. The amount of type II collagen in the intercellular matrix of cartilage is significantly reduced against the background of musculoskeletal system diseases. The basis of articular cartilage is hyaline cartilage tissue consisting of chondrocytes with tissue-specific antigens
O.A. Shavlovskaya +2 more
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An Overview of a Novel, Water-Soluble Undenatured Type II Collagen (NEXT-II)
Journal of the American College of Nutrition, 2015Osteoarthritis, the most common form of arthritis, is a crippling, chronic debilitating bone disease that commonly affects humans, dogs, and horses. Inflammation and inflammatory responses are key factors for causing swelling, redness, pain, and loss of movement in arthritic animals and humans.We developed a novel, water-soluble, undenatured type II ...
Orie, Yoshinari +2 more
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Food & Function, 2023
The differences in the improvement effects of SC II, IC II and celecoxib on MIA-induced osteoarthritis model rats were compared, and the results suggest SC II may be superior to IC II in improving osteoarthritis in rats.
Rong Xu +5 more
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The differences in the improvement effects of SC II, IC II and celecoxib on MIA-induced osteoarthritis model rats were compared, and the results suggest SC II may be superior to IC II in improving osteoarthritis in rats.
Rong Xu +5 more
openaire +2 more sources