Results 121 to 130 of about 35,714 (290)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Sectoral Diversity in Regions, Empirical Tests [PDF]
The present paper studies localisation economies from a service industry perspective and especially the spatial location structure of the consumer- and producer service sector in Sweden.
Jonas Kjellgren
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Humanities & Social Sciences CommunicationsDigital-green fusion plays a vital role in advancing sustainable urban ecology. This study characterizes the levels of digital and green development through the digital economy (DE) and industrial ecologization (IEE), and explores their integrated ...
Meijuan Hu +3 more
doaj +1 more source
SystemsEntrepreneurial resources are crucial to the success of ventures in underdeveloped regions. Leveraging limited resources to enhance entrepreneurial effectiveness and contribute to poverty alleviation through entrepreneurship has attracted significant academic interest.
Sheng Ouyang +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Region and regionalism ¿autonomy or integration? [PDF]
, 2004 The question over identity, autonomy and integration between regions, about the requirement to define politics and aims, still prevails. The Colombian Caribbean region has been characterized in accordance with the nation historical state of affairs; the ...
Restrepo, Juan Guillermo
core
Health care inequality under different medical insurance schemes in a socioeconomically underdeveloped region of China: a propensity score matching analysis. [PDF]
BMC Public Health, 2019 Xian W +6 more
europepmc +1 more source