Results 101 to 110 of about 35,714 (290)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Economic development in the Kimberley region of Western Australia: a history and dependency theory perspective [PDF]
, 2004 [Abstract]: The focus of the research undertaken for this dissertation is the economic development of the Kimberley region of Western Australia. The period studied is, approximately, the one hundred years from 1900–2000.
Sharpe, Leslie J.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Development of Universities in Underdeveloped Regions in Perspective of HE Localization [PDF]
, 2013 高等教育地方化导致不同地区高等教育发展不平衡。身处欠发达地区的地方本科院校发展面临诸多瓶颈,应坚持“依托地方、立足地方、服务地方“的办学理念,在满足地方需求的基础上特色办学、错位发展。The localization of higher education has led to the imbalanced development of higher education in different regions.The local universities in the underdeveloped ...
赖晓琴
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The Evolution of Regional Disparities in the Rural Areas of Muscelele Argeşului [PDF]
Romanian Review of Regional Studies, 2012 Regional disparities are clearly a significant challenge to the new European construction. Disparities are often sources of instability but are also sources of antagonism and unrest.
CĂTĂLINA CÂRSTEA
doaj
Analysis in-Depth of the Factors that Impact the Development of E-Commerce in Underdeveloped Areas from the Perspective of Operating Process [PDF]
, 2014 The booming e-commerce has played an important role in the growth of regional economy and the e-commerce of underdeveloped regions has been developing rapidly as well.
Wu, Liang, Tang, Panpan, Zhang, Lei
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Some aspects of the labour force mobility of the Drava region [PDF]
, 2013 While one can experience the growth of mobility in the 21st century, the increasing spatial distances between the workplaces and residences make it a key question whether the theoretical broadening of transportation opportunities can treat the employment
Alpek, Balázs Levente, Tésits, Róbert
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source