Results 81 to 90 of about 35,714 (290)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

A prospective study of causes of death in rural Gadchiroli, an underdeveloped district of India (2011-2013) [PDF]

open access: yes, 2019
# Background Reliable information on causes of death to understand health priorities is rare from rural underdeveloped regions of India but is needed to direct health care response.
Abhay Bang   +6 more
core   +1 more source

Alcohol Drinking and Psychological Health Outcome A Cross-Sectional Study in an Underdeveloped Region of China

open access: yesEuropean Journal of Psychology Open
: Objective: This paper explores the relationship between alcohol consumption and psychological health outcome in an economically underdeveloped area of China.
Ziting Wu   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

THE IMPORTANCE AND PUBLIC ACCEPTANCE OF BIOMASS AND “GREEN ENERGY”– THE EXAMPLE OF AN UNDERDEVELOPED HUNGARIAN REGION [PDF]

open access: yes, 2017
The future of biomass energy in the global (national, regional and local) energy system depends on many major factors, among others on the attitude of society to the renewable energy resources including the biomass energy.
Patkós, Csaba   +4 more
core   +1 more source

Perilaku anak sekolah dasar daerah tertinggal tentang pemeliharaan kesehatan gigi

Underdeveloped area elementary school children’s behaviour towards dental health care

open access: yesJurnal Kedokteran Gigi Universitas Padjadjaran, 2017
Pendahuluan: Perilaku pemeliharaan kesehatan gigi merupakan kegiatan individu untuk mencegah terjadinya penyakit karies dan periodontal yang terbentuk dari pengetahuan, sikap dan tindakan.
Sonia Rama   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

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