Results 91 to 100 of about 35,714 (290)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A nonlinear integer programming model for expanding the transportation system of an underdeveloped country or region. [PDF]
, 1969 A nonlinear integer programming model for expanding the transportation system of an underdeveloped country is presented. The model uses integer 0-1 decision variables. The basic model has linear constraints and a nonlinear objective function.
Martin, Bernard Michael
core
A dinâmica populacional dos países desenvolvidos e subdesenvolvidos Population dynamics on the developed and underdeveloped countries [PDF]
, 1971 Analisam-se os principais fatôres que contribuiram para a dinâmica populacional dos países desenvolvidos e subdesenvolvidos, a política por êles adotada, bem como a aplicação da demografia em saúde pública.
João Yunes, Yunes, João
core +1 more source
Overview of the use of clean cookstoves in the Brazilian semiarid region
Sustentabilidade em Debate, 2019 Wood cookstoves are common in the Brazilian semiarid region. Most families use traditional versions, which have a series of social, environmental and health-related impacts. “Improved cookstoves” refer to cleaner and more efficient cookstoves.
Javier Mazorra +7 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Economic Analysis of the Lagging-behind Development of the County-region Economy in the Underdeveloped Region [PDF]
, 2005 内容提要在回顾了相关理论之后，从第二章起，本文对我国东西部县域经济进行了比较分析：我国东部地区经济发达的县域较多，而西部地区较少，我国的贫困县大多分布在西部地区。西部地区的县域经济发展存在以下一些问题：一是县域经济实力弱，二是产业结构偏重于第一产业，第二三产业不发达，第三是西部地区县域经济存在明显的二元经济特征。四是西部地区在县域经济的管理方面受原来计划经济的影响较严重，五是人才和科技发展不足。第三章分析了区位因素对我国西部地区县域经济的影响。西部地区山地多平地少，生态脆弱，这限制了西部地区农业的发展 ...
张树全
core
Study on edge villages based on cross-region healthcare-seeking behavior
International Journal of Health GeographicsBackground This study addresses spatial disparities in rural healthcare by introducing the concept of edge village —communities where a misalignment between administrative boundaries and functional hospital service areas (HSAs) leads to prevalent cross ...
Lulu Liu +3 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
A SOCIO-ECONOMIC ANALYSIS OF THE RURAL AREA IN THE WESTERN REGION [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014 The analysis presented in this paper points out the fact that we need to make fundamental improvements in the Western Region if we want to be able to face the future challenges generated by new investments with a view to increase economic activities, to ...
Nicoleta MATEOC-SÎRB +5 more
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