Results 121 to 130 of about 614,915 (288)

Causas múltiplas de morte relacionadas à tuberculose no Estado de São Paulo, 1998

Revista de Saúde Pública
OBJETIVO: Estudar a mortalidade relacionada à tuberculose no Estado de São Paulo segundo causas múltiplas de morte, e suas inter-relações com outras causas básicas.
Augusto Hasiak Santo, Celso Escobar Pinheiro, Margarete Silva Jordani   +2 more
doaj  

Regional changes and variability of mortality rates from chronic ischemic heart disease in the Russian Federation in 2014-2023

Кардиоваскулярная терапия и профилактика
Aim. To assess the changes and variability of standardized mortality rates (SMR) from various types of chronic ischemic heart disease (CIHD) in the Russian Federation and its regions in 2014-2023.Material and methods.
R. N. Shepel, I. V. Samorodskaya, E. P. Kakorina, O. M. Drapkina   +3 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US.

JAMA Netw Open, 2023
Flaxman S, Whittaker C, Semenova E, Rashid T, Parks RM, Blenkinsop A, Unwin HJT, Mishra S, Bhatt S, Gurdasani D, Ratmann O.   +10 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Mechanisms Underlying Trabecular Meshwork Cell Death Caused by Mutant Myocilin Expression [PDF]

, 2011
Dong Hui Lim, Seongsoo Sohn, Tae Eun Kim, Changwon Kee   +3 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Mortalidade por asma no Município de São Paulo, Brasil

Revista de Saúde Pública
OBJETIVO: Quantificar e comparar a mortalidade por asma como causa básica, considerando as variáveis sexo, idade e sazonalidade. MÉTODO: Os dados foram obtidos de atestados de óbito com código 493 (CID-9) ocorridos entre cinco e 34 anos nos triênios ...
Evani Marzagão Beringhs Rio, Paulo Rogério Gallo, Arnaldo A Franco de Siqueira   +2 more
doaj