Results 71 to 80 of about 4,354,150 (246)

Multiple Hierarchical Cross-Scale Transformer for Remote Sensing Scene Classification

Remote Sensing
The Transformer model can capture global contextual information but does not have an inherent inductive bias. In contrast, convolutional neural networks (CNNs) are highly praised in computer vision due to their strong inductive bias and local spatial ...
Dan Zhang, Wenping Ma, Licheng Jiao, Xu Liu, Yuting Yang, Fang Liu   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Unraveling electronic correlations in warm dense quantum plasmas

Nature Communications
The study of matter at extreme densities and temperatures has emerged as a highly active frontier at the interface of plasma physics, material science and quantum chemistry with relevance for planetary modeling and inertial confinement fusion.
Tobias Dornheim, Tilo Döppner, Panagiotis Tolias, Maximilian P. Böhme, Luke B. Fletcher, Thomas Gawne, Frank R. Graziani, Dominik Kraus, Michael J. MacDonald, Zhandos A. Moldabekov, Sebastian Schwalbe, Dirk O. Gericke, Jan Vorberger   +12 more
doaj   +1 more source

A Review on Deep Learning Methods for Glioma Segmentation, Limitations, and Future Perspectives

Journal of Imaging
Accurate and automated segmentation of gliomas from Magnetic Resonance Imaging (MRI) is crucial for effective diagnosis, treatment planning, and patient monitoring.
Cecilia Diana-Albelda, Álvaro García-Martín, Jesus Bescos   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Enhancing Assisted Living Technology with Extended Visual Memory

i-Perception, 2011
Human vision and memory are powerful cognitive faculties by which we understand the world. However, they are imperfect and further, subject to deterioration with age.
Joo-Hwee Lim, Si-Ying Liu
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source