Results 81 to 90 of about 4,602 (244)

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

City transport as a factor of availability and distribution of activity centres

MATEC Web of Conferences, 2018
Labor connections determine territorial unity and spatiotemporal settlement patterns in the structure of city connections. Labor connections define the life of the city, the distribution of the centers of gravity, and the functioning of its main ...
Gorovoy Alexander, Merzlikin Igor, Kondratyeva Tatyana   +2 more
doaj   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

CALCULATION METHOD OF RESPONSE OF CLUSTERED PIPELINES SUBJECTED TO UNEVEN GROUND SETTLEMENTS

Doboku Gakkai Ronbunshu, 1997
近年, 電力ケーブル保護管として多条多段配管が使用されつつあるが, 多条多段配管に関する不等沈下計算法は未だ確立されていない. 1995年01月17日に発生した兵庫県南部地震ではライフライン施設も例外なく甚大な被害を受けた. 地震時不等沈下も含めてライフライン施設の耐震評価手法を早急に整備するのは重要な課題である.本研究では, 以上のことを踏まえて, いままで不等沈下設計計算法が確立できていなかった多条多段配管を研究対象として, 実験値を説明できるモデルの設定と上・下段管の応答の相違を明らかにすることおよび継手の設計を目的として, 多条多段配管の不等沈下設計計算法を提案するとともに, 継手特性と地盤ばね係数の設定および取付部の条件などが管路の応答に与える影響を検討する.
Shiro Takada, Tengyan Li, Jyunji Higashi
openaire   +2 more sources

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Experimental and Finite Element Analyses of Adjustable Foundation Bolts in Transmission Towers

Buildings
Uneven settlement of transmission tower foundations can result in catastrophic events, such as tower collapse and line failures, disrupting power transmission operations.
Huajie Yin, Xianzhi Xiao, Zhi Huang, Tengfei Zhao, Mojia Huang   +4 more
doaj   +1 more source

Assessment of metro running safety and comfort under uneven tunnel settlement

Journal of Physics: Conference Series
Abstract Uneven tunnel settlement has adverse effects of varying degrees on tunnel structures, track structures, and metro train operating conditions. With increasing emphasis on the safety and comfort of metro operations, it is necessary to assess the metro running safety and comfort under uneven settlement conditions.
Xianfeng Zhang, Long Wang, Jinfeng Zhang
openaire   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Analysis of Frame Structure under Uneven Settlement and Earthquake [PDF]

Proceedings of the 2015 International Conference on Advanced Engineering Materials and Technology, 2015
Huiling Wang, Fei Qin, Peng Deng
openaire   +1 more source