Results 81 to 90 of about 1,905,453 (180)

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Long-term low-dose erythromycin in patients with unexplained chronic cough: a double-blind placebo controlled trial.

, 2010
AIMS: Unexplained chronic cough is a common condition with no satisfactory treatments. Previous work has suggested that cough may be linked to neutrophilic airway inflammation. This study tested the hypothesis that long-term low-dose erythromycin reduces
N. Yousaf, S. Birring, D. Parker, S. Matos, W. Monteiro, I. D. Pavord   +5 more
core   +1 more source

Survival outcomes in dogs treated with vinorelbine‐based adjuvant treatment following surgical resection of grade II and III pulmonary carcinoma

Journal of Small Animal Practice, EarlyView.
Objectives Pulmonary carcinoma in dogs is commonly managed with surgical resection; however, the role of adjuvant chemotherapy for grade II and III carcinomas remains unclear. This retrospective multicentre study investigated the outcomes in dogs treated with vinorelbine‐based adjuvant treatment (as monotherapy or combined chemotherapy) following ...
N. Wong, L. Brockley, S. Rajan, J. Yu
wiley   +1 more source

Chronic cough diagnosis, treatment, and referral practices among family physicians in the United States: a survey study

BMC Primary Care
Background Cough is one of the most common presenting problems for patients in primary care and is largely managed in primary care clinical settings. Family physicians’ familiarity with chronic cough guidelines and the extent to which these guidelines ...
Joel B. Shields, Elisabeth Callen, Natalia Y. Loskutova, Jonathan Schelfhout, Christina M. Hester   +4 more
doaj   +1 more source

Aspergillus tracheobronchitis with Birt-Hogg-Dubè syndrome as a rare cause of chronic cough

BMC Pulmonary Medicine, 2022
Background Aspergillus tracheobronchitis (ATB) is confined as a condition of chronic superficial infection of tracheobronchial tree. Its diagnosis is difficult due to atypical manifestations and low detective rate of Aspergillus thus far.
Lianrong Huang, Fang Yi, Chen Zhan, Kefang Lai   +3 more
doaj   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Quantitative measurement properties and score interpretation of the Cough Severity Diary in patients with chronic cough

Therapeutic Advances in Respiratory Disease, 2020
Aims: The Cough Severity Diary (CSD) was developed in accordance with the FDA guidance for patient-reported outcome measures and is focused on capturing the patient’s perception of cough in terms of frequency, intensity, and disruption due to their cough.
Allison Martin Nguyen, Elizabeth Bacci, Peter Dicpinigaitis, Margaret Vernon   +3 more
doaj   +1 more source

Case Report of a Rapidly Progressive Indolent T‐Cell Lymphoma of the Gastrointestinal Tract

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Indolent T‐cell lymphoma of the gastrointestinal tract (iTCL‐GI) is a relatively newly recognized disease entity. iTCL‐GI was first proposed by Perry et al. in 2013, before it was formally incorporated as a distinct disease category in the fifth edition of the World Health Organization Classification of Hematolymphoid Tumors: Lymphoid ...
Keitaro Shibuya, Akiko Tamura, Daiki Yafuso, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Hiromichi Shimizu, Toshimitsu Fujii, Kazuo Ohtsuka, Ryuichi Okamoto   +9 more
wiley   +1 more source

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, Volume 101, Issue 11, Page 2799-2811, November 2026.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

Cerebellar ataxia, neuropathy and vestibular areflexia syndrome: a neurogenic cough prototype

ERJ Open Research
Chronic cough is a frequent disorder that is defined by cough of more than 8 weeks duration. Despite extensive investigation, some patients exhibit no aetiology and others do not respond to specific treatments directed against apparent causes of cough ...
Laurent Guilleminault, Stuart B. Mazzone, Pauline Chazelas, Simon Frachet, Anne-Sophie Lia, Laurent Magy   +5 more
doaj   +1 more source