Results 31 to 40 of about 12,571,370 (238)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A grand unified theory of trust
Trust is a vital, yet nebulous philosophical concept which has persistently defied singular definition despite undergoing millennia of research scrutiny.
Archer, Matthew Christopher
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
This study proposes a unified field theory model that connects electromagnetic and gravitational phenomena through a new concept called the “gravitational magnetism equation.
Hidetoshi Kageyama
core +1 more source
Unified Dark Matter models with fast transition [PDF]
, 2010 We investigate the general properties of Unified Dark Matter (UDM) fluid models where the pressure and the energy density are linked by a barotropic equation of state (EoS) p = p(ρ) and the perturbations are adiabatic.
Davide Pietrobon +12 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A unified field chart of urban sustainability
, 2018 This research paper, the third in a three-part series of papers on the Unified Field Chart as conceived by Maharishi Mahesh Yogi, presents an integrated approach to organising the discipline of Urban Sustainability.
Fergusson, Lee +2 more
core
Organizational commitment of managerial employees: a unified theory and antecedents
, 2010 Much has been written about organizational commitment in the past twenty five years and these studies have significantly contributed to the extant understanding of the concept.
Baksh, Abdul M.
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source