Results 61 to 70 of about 144,849 (258)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Avaliação de desempenho de sistemas de saúde e gerencialismo na gestão pública brasileira

Saúde e Sociedade
Resumo Em saúde, a lógica da nova gestão pública considera os serviços sanitários como atividades públicas não-estatais, portanto executáveis por entes privados. Nesse cenário, a função de controle alcança o proscênio na discussão sobre a consolidação do
Leonardo Carnut, Paulo Capel Narvai
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Social Participation: the construction of democracy in Brazilian health [PDF]

Revista Brasileira em Promoção da Saúde, 2011
Objective: To verify the theoretical construction of the terms “social participation” and “social control” relating them to the process of construction of democracy in Brazilian health.
Cibelle Cristina da Silva Santos, Raquel Littério de Bastos   +1 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Parliamentary amendments aimed at the Brazilian Unified National Health System and the reelection of municipal mayors in Brazil in 2024 [PDF]

Cadernos de Saúde Pública
: In Brazil, as of 2016, there has been an increase in the share of parliamentary amendments (PAs) in the federal budget, transferred from the Brazilian Ministry of Health to municipalities to fund the Brazilian Unified National Health System (SUS). This
João Gabriel Ribeiro Pessanha Leal, Luciana Dias de Lima, Frederico Bertholini Santos Rodrigues, André Schimidt da Silva   +3 more
doaj   +1 more source

Social participation in the health technology incorporation process into Unified Health System

Revista de Saúde Pública, 2019
OBJECTIVE: To describe the current process of social participation in the incorporation of health technologies in Brazil, within the context of the Unified Health System (SUS). METHODS: A descriptive study was conducted based on the analysis of official records of the actions of the National Committee for Health Technology Incorporation into Unified ...
Dayani Galato, Emília Vitória da Silva, Maria Sharmila Alina de Sousa, Aline Silveira Silva   +3 more
openaire   +6 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

O Sistema Único de Saúde (SUS) como um macrossistema: território, técnica e política

GEOUSP: Espaço e Tempo, 2017
O Sistema Único de Saúde (SUS) constitui um macrossistema no território brasileiro ao agregar ampla e diversa materialidade, organizando e gerenciando seus fluxos.
Luis Henrique Leandro Ribeiro
doaj   +1 more source