Results 71 to 80 of about 144,849 (258)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Brazil’s Unified Health System: the fight for a universal right in an unequal country

Salud Pública de México
This article analyzes Brazil's Unified Health System (SUS), established by the 1988 Constitution. The article initially presents the previous trajectory of national health policy and the context of democratization in the 1980s, which favored health ...
Cristiani Vieira-Machado, Luciana Dias de Lima   +1 more
doaj   +1 more source

EVALUATION OF THE CARE GIVEN TO DIABETIC SERVICE USERS IN A HEALTH CARE UNIT

Cogitare Enfermagem, 2011
This study aims to evaluate the care programmed for diabetics in a Basic Healthcare Unit of the Brazilian National Health in a county in the metropolitan region of Curitiba, in the state of Paraná.
Aline Mariana Gafuri, Beatris Mario Martin, Carolina Passos Rocha, Fernanda Rackes da Silva, Roberta Luiza Longo, Guilherme Souza Cavalcanti de Albuquerque   +5 more
doaj   +1 more source

Unified health system 30th birthday: health surveillance.

Ciencia & saude coletiva, 2018
This article presents an overview of the nature, functions and history of health surveillance in the structure of the Brazilian Unified Health System (SUS). Bibliographical sources and official documents were used, with references from the careers of the authors, who have worked in health surveillance.
José Agenor Alvares da, Silva, Ediná Alves, Costa, Geraldo, Lucchese   +2 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Family Health Support Center in the perspective of physicians and nurses

Escola Anna Nery, 2019
Objective: To analyze the physician’s and nurse’s perceptions about the actions developed by the Family Health Support Center (FHSC). Method: A qualitative study, conducted with 16 physicians and 23 nurses.
Jaqueline Carvalho e Silva Sales, Camilla de Oliveira Castelo Branco, Jordana Fonseca Reis, Polyana Norberta Mendes, Fernando José Guedes da Silva Júnior, Andreia Rodrigues Moura da Costa Valle   +5 more
doaj   +2 more sources

Judicialization of health and the Unified Health System: integrative review

, 2020
Objective: to analyze the implications, challenges and perspectives of phenomenon to the Unified Health System (SUS, in portuguese), as well as the main nature of requests. Methodology: it is an integrative literature review. The database chosen was the Virtual Health Library and was included full articles in English or Portuguese, available online ...
Costa, Kemily Benini, Silva, Lia Mota e, Ogata, Marcia Niituma, Costa, Kemily Benini, Silva, Lia Mota e, Ogata, Marcia Niituma, Costa, Kemily Benini, Silva, Lia Mota e, Ogata, Marcia Niituma   +8 more
openaire   +1 more source

Polypharmacy:

Revista de Saúde Pública, 2017
OBJECTIVE: To characterize the polypharmacy in primary health care patients and to identify its associated factors. METHODS: This is a cross-sectional, exploratory, and evaluative study, part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos – Serviços, 2015 (PNAUM – National Survey on Access, Use and ...
Nascimento, Renata Cristina Rezende Macedo, Álvares, Juliana, Junior, Augusto Afonso Guerra, Gomes, Isabel Cristina, Silveira, Micheline Rosa, Costa, Ediná Alves, Leite, Silvana Nair, Costa, Karen Sarmento, Soeiro, Orlando Mario, Guibu, Ione Aquemi, Karnikowski, Margô Gomes de Oliveira, Acurcio, Francisco de Assis Acurcio   +11 more
openaire   +6 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source