Results 51 to 60 of about 511 (254)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Enhancing Power Quality with PDO-FOPID Controller in Unified Power Quality Conditioner for Grid-Connected Hybrid Renewables

Nigerian Journal of Technological Development, 2023
Addressing the pressing research problem of power fluctuations and grid harmonics in the integration of renewable energy, our proposed control strategy utilizes the Prairie Dog Optimization Fractional Order Proportional Integral Derivative (PDO-FOPID ...
NAGARAJU SAMALA, Chandramouli Bethi
doaj  

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Artificial ecosystem optimized neural network controlled unified power quality conditioner for microgrid application

Energy Informatics, 2023
Unified power quality conditioner is chiefly employed to offer power quality improvement, especially in grid connected mode of operation in microgrid applications.
Rajeev Ratnakaran, Gomathi Bhavani Rajagopalan, Asma Fathima   +2 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Comprehensive Power Quality Management for Transformerless Unified Power Quality Conditioner Under Multiple Operating Conditions

Shanghai Jiaotong Daxue xuebao
To address the power quality problems caused by power electronic loads, a two-leg topology-based transformerless unified power quality conditioner (TLTT-UPQC) is proposed, which can overcome the volume, weight, and magnetic saturation of power frequency ...
FU Zhe, ZHANG Qi, LIU Yang, WAN Bohao, WANG Ting, SUN Yanfei
doaj   +1 more source

Study of Unified Power Quality Conditioner for Power Quality Improvement

International Journal Of Engineering And Computer Science, 2016
These In a powers system network there are many problems related to power quality. So to improve power quality of a system we use different devices such as active power filters. Active power filters are classified into two types that is Shunt Active Power Filter (APF) and Series Active Power Filter (APF) and combination of both is known as UPQC ...
openaire   +1 more source