Results 71 to 80 of about 511 (254)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Control and Protection of Unified Power Quality Conditioners: A Review

open access: yesIEEE Open Journal of Power Electronics
The transition toward converter-dominated distribution grids, driven by distributed generation, storage, and increasingly nonlinear demand, is intensifying power-quality disturbances and exposing limitations of passive mitigation.
Mark Frederick Puleston   +3 more
doaj   +1 more source

Effective Renewable Source Integration using Unified Power Quality Conditioner with Power Quality Enhancement in Three Phase System

open access: yesMATEC Web of Conferences, 2018
This paper proposes a modified control strategy for unified Power Quality conditioner to alleviate voltage and current abnormalities in three phase system. Renewable source integration and nonlinear loads depreciates Power Quality of the system.
Suresh P., Gowri Manohar T.
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

ANN based control scheme for a three-level converter based unified power quality conditioner

open access: yesJournal of Electrical Systems and Information Technology, 2018
Unified power quality conditioner (UPQC) has been used convincingly to mitigate most of the electric power quality issues. Conventional control schemes such as Synchronous Reference Fame (SRF) and P-Q theory based control involves abc to/from dq/αb ...
Sudheer Vinnakoti, Venkata Reddy Kota
doaj   +1 more source

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