Results 51 to 60 of about 1,679,233 (282)

Uniform Bounds for Sampling Expansions

Journal of Approximation Theory, 1998
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Metric Uniformization and Spectral Bounds for Graphs [PDF]

Geometric and Functional Analysis, 2011
We present a method for proving upper bounds on the eigenvalues of the graph Laplacian. A main step involves choosing an appropriate "Riemannian" metric to uniformize the geometry of the graph. In many interesting cases, the existence of such a metric is shown by examining the combinatorics of special types of flows.
Kelner, Jonathan Adam, Lee, James R., Price, Gregory N., Teng, Shang-Hua   +3 more
openaire   +5 more sources

Optimal PAC Bounds without Uniform Convergence

2023 IEEE 64th Annual Symposium on Foundations of Computer Science (FOCS), 2023
In statistical learning theory, determining the sample complexity of realizable binary classification for VC classes was a long-standing open problem. The results of Simon and Hanneke established sharp upper bounds in this setting. However, the reliance of their argument on the uniform convergence principle limits its applicability to more general ...
Ishaq Aden-Ali, Yeshwanth Cherapanamjeri, Abhishek Shetty, Nikita Zhivotovskiy   +3 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Non-uniform Berry–Esseen bounds via Malliavin–Stein method

Comptes Rendus. Mathématique
In this paper, we establish non-uniform Berry–Esseen bounds by means of the Malliavin–Stein method. Applications to the multiple Wiener–Itô integrals and the exponential functionals of Brownian motion are given to illustrate the theory.
Tien Dung, Nguyen, Vi, Le, Phuong Thuy, Pham Thi   +2 more
doaj   +1 more source

On uniform bounds of primeness in matrix rings [PDF]

Journal of the Australian Mathematical Society, 2004
AbstractA subset S of an associative ring R is a uniform insulator for R provided a S b ≠ 0 for any nonzero a, b ∈ R. The ring R is called uniformly strongly prime of bound m if R has uniform insulators and the smallest of those has cardinality m. Here we compute these bounds for matrix rings over fields and obtain refinements of some results of van ...
Beidar, Konstantin I., Wisbauer, Robert
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source