Results 71 to 80 of about 1,679,233 (282)
Regulating Constraint-Following Bound for Uncertain Mechanical Systems: An Indirect Control Approach
IEEE Access, 2020 This paper proposes an indirect approach of constraint-following control for mechanical systems with (possibly fast) time-varying uncertainty. It proposes to design controller for the system to render bounded constraint-following error.
Qinqin Sun +3 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Uniform Bounds for Period Integrals and Sparse Equidistribution [PDF]
International Mathematics Research Notices, 2015 23 ...
Tanis, J., Vishe, P.
openaire +4 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Uniform Convergence Bounds for Codec Selection
CoRR, 2018 We frame the problem of selecting an optimal audio encoding scheme as a supervised learning task. Through uniform convergence theory, we guarantee approximately optimal codec selection while controlling for selection bias. We present rigorous statistical guarantees for the codec selection problem that hold for arbitrary distributions over audio ...
Clayton Sanford +2 more
openaire +3 more sources
Non-uniform corner cutting [PDF]
, 1988 The convergence of a non-uniform corner cutting process is investigated. It is shown that the limit curve will be differentiable provided the proportions of the corner cuts are kept within appropriate constraints.
Gregory, JA, Qu, R
core +4 more sources
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source