Results 61 to 70 of about 1,282,961 (279)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Non-uniform Berry–Esseen bounds via Malliavin–Stein method

Comptes Rendus. Mathématique
In this paper, we establish non-uniform Berry–Esseen bounds by means of the Malliavin–Stein method. Applications to the multiple Wiener–Itô integrals and the exponential functionals of Brownian motion are given to illustrate the theory.
Tien Dung, Nguyen, Vi, Le, Phuong Thuy, Pham Thi   +2 more
doaj   +1 more source

Smoothing metrics on closed Riemannian manifolds through the Ricci flow

, 2011
Under the assumption of the uniform local Sobolev inequality, it is proved that Riemannian metrics with an absolute Ricci curvature bound and a small Riemannian curvature integral bound can be smoothed to having a sectional curvature bound.
Yang, Yunyan
core   +1 more source

Optimal PAC Bounds without Uniform Convergence

2023 IEEE 64th Annual Symposium on Foundations of Computer Science (FOCS), 2023
In statistical learning theory, determining the sample complexity of realizable binary classification for VC classes was a long-standing open problem. The results of Simon and Hanneke established sharp upper bounds in this setting. However, the reliance of their argument on the uniform convergence principle limits its applicability to more general ...
Ishaq Aden-Ali, Yeshwanth Cherapanamjeri, Abhishek Shetty, Nikita Zhivotovskiy   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

New bounds on Poisson approximation to the distribution of a sum of negative binomial random variables [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2018
The Stein-Chen method is usedto give new bounds, non-uniform bounds, for the distances between the distribution of a sum of independent negative binomial random variables and a Poisson distribution with mean, where ri and pi = 1-qi are parameters of ...
Kanint Teerapabolarn
doaj   +1 more source

DP-colorings of uniform hypergraphs and splittings of Boolean hypercube into faces

, 2022
We develop a connection between DP-colorings of $k$-uniform hypergraphs of order $n$ and coverings of $n$-dimensional Boolean hypercube by pairs of antipodal $(n-k)$-dimensional faces. Bernshteyn and Kostochka established that the lower bound on edges in
Potapov, Vladimir N.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Randi´c Matrix and Randi´c Energy of Uniform Hypergraphs [PDF]

Mathematics Interdisciplinary Research
‎The Randi´c matrix $R=[r_{ij}]$ of a graph $ G=(V,E) $ was defined as $r_{ij}=\frac{1}{\sqrt{d_id_j}}$ if vertices $v_i$ and $v_j$ are adjacent and $r_{ij}=0$ otherwise‎, ‎where $d_i$ is the degree of the vertex $v_i\in V$‎.
Gholam Hassan Shirdel, Ameneh Mortezaee, Laith Alaameri   +2 more
doaj   +1 more source