Results 41 to 50 of about 726,899 (278)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

On a waveguide with frequently alternating boundary conditions: homogenized Neumann condition

open access: yes, 2010
We consider a waveguide modeled by the Laplacian in a straight planar strip. The Dirichlet boundary condition is taken on the upper boundary, while on the lower boundary we impose periodically alternating Dirichlet and Neumann condition assuming the ...
Borisov, Denis   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Numerical treatment for the solution of singularly perturbed pseudo-parabolic problem on an equidistributed grid

open access: yesNonlinear Engineering, 2020
The initial-boundary value problem for a pseudo-parabolic equation exhibiting initial layer is considered. For solving this problem numerically independence of the perturbation parameter, we propose a difference scheme which consists of the implicit ...
Mohapatra Jugal, Shakti Deepti
doaj   +1 more source

Numerical Solution of Stochastic Partial Differential Equations with Correlated Noise [PDF]

open access: yes, 2013
In this paper we investigate the numerical solution of stochastic partial differential equations (SPDEs) for a wider class of stochastic equations. We focus on non-diagonal colored noise instead of the usual space-time white noise. By applying a spectral
Blömker, Dirk, Kamrani, Minoo
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

A uniform Tauberian theorem in optimal control [PDF]

open access: yes, 2010
In an optimal control framework, we consider the value $V_T(x)$ of the problem starting from state $x$ with finite horizon $T$, as well as the value $V_\lambda(x)$ of the $\lambda$-discounted problem starting from $x$.
Oliu-Barton, Miquel, Vigeral, Guillaume
core  

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang   +22 more
wiley   +1 more source

Uniform Topologies on Types [PDF]

open access: yes
We study the robustness of interim correlated rationalizability to perturbations of higher-order beliefs. We introduce a new metric topology on the universal type space, called uniform weak topology, under which two types are close if they have similar ...
Alfredo Di Tillio   +3 more
core   +3 more sources

Topologies between compact and uniform convergence on function spaces

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1993
This paper studies two topologies on the set of all continuous real-valued functions on a Tychonoff space which lie between the topologies of compact convergence and uniform convergence.
S. Kundu, R. A. McCoy
doaj   +1 more source

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