Results 61 to 70 of about 1,619,646 (284)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Uniform properties and hyperspace topologies for ℵ-uniformities

Topology and its Applications, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

O UNIFORME DA ENFERMEIRA VISTO PELO PACIENTE, ENFERMEIRA E DOCENTE DE ENFERMAGEM

Revista da Escola de Enfermagem da USP
O presente trabalho teve por objetivo verificar a percepção de pacientes, enfermeiras e docentes de enfermagem, de diferentes instituições de saúde, sobre a imagem da enfermeira baseada em modelos de uniformes mais comumente usados na cidade de São Paulo.
Maria Júlia Paes da Silva, Maguida Costa Stefanelli, Lina Monetta, Thelma Leite de Araujo   +3 more
doaj   +1 more source

Los problemas derivados de la coexistencia de las reglamentaciones sobre los créditos documentarios stand-by y sobre las garantías independientes

Estudios de Deusto, 2015
Sumario: I. La naturaleza y modalidades de los créditos stand-by. 1. El crédito stand-by financiero. 2. La utilización del crédito stand-by en garantía del pago del precio. II.
Javier San Juan Crucelaegui
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Régimen jurídico aplicable a la compraventa internacional en Colombia

Revista de Derecho, 2019
Con el fin de incrementar la seguridad jurídica de la contratación internacional, la ley aplicable al contrato debe contar con un elevado nivel de previsibilidad.
WILLIAM FERNANDO MARTÍNEZ LUNA
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Sobre tres alternativas para discutir y repensar el ejercicio de la abogacía desde una óptica social

Jurídica Ibero, 2018
El presente artículo explora tres diferentes alternativas para repensar el ejercicio de la abogacía desde ópticas no uniformes ni monolíticas. Al conjugar actores y campos diversos es posible que la profesión encuentre maneras que generen mayores ...
Juan Jesús Garza Onofre
doaj   +1 more source