Results 51 to 60 of about 1,829,283 (315)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mesure de gradients de déformations par fibre optique = Strain gradient measurement with optical fiber [PDF]

, 2009
National audienceCet article porte sur l'utilisation de fibre optique à réseau de Bragg pour mesurer des profils de déformations non uniformes. Les réseaux de Bragg permettent facilement de mesurer des déformations uniformes, notre méthode est donc ...
Boisrobert, C., Casari, Pascal, Chapeleau, Xavier, Daher, N., Leduc, D., Lupi, Cyril, Morvan, Pierre-Antoine   +6 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Preliminar de rendimiento de líneas uniformes de arroz.

Agronomía Mesoamericana, 2016
Con el objetivo de seleccionar y poner a disposición del Programa de Granos Básicos un germoplasma promisorio de arroz, con alto potencial de rendimiento, resistente o tolerante a enfermedades fungosas, principalmente a piricularia y buena arquitectura ...
Wilfredo Castañeda, Luis Guerrero
doaj   +1 more source

Métodos para superar a dormência de sementes florestais tropicais. [PDF]

, 2018
Informacoes tecnicas sobre metodos praticos e eficazes para superar a dormencia de sementes de especies florestais tropicais em Manaus, AM (Brasil), visando a producao de mudas uniformes e em quantidades suficientes para subsidiar programas de ...
AZEVEDO, C. P. de, GARCIA, L. C.
core   +1 more source

Uniform Sharing [PDF]

, 2019
Collective models have become the go-to framework for intra-household allocations. Available empirical collective models are built for fixed sets of household members and accommodate diversity in household structures with difficulty. Individual-level data on food consumption from Bangladesh provides an opportunity to build a parsimonious model that ...
openaire   +2 more sources

Educação e Moda: Uniformes de Enfermagem na Segunda Guerra Mundial

ModaPalavra e-periódico, 2010
As enfermeiras que participaram da Segunda Guerra Mundial escreveram um importante capítulo para a história das mulheres e da enfermagem. Este texto tem por objetivo abordar essa história na perspectiva da educação e da moda. Por intermédio dos relatos e
Ivana Guilherme Simili, Priscila Camacho, Pollyanna Ponte   +2 more
doaj   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source