Results 41 to 50 of about 1,829,283 (315)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Limite non visqueuse pour le système de Navier-Stokes dans un espace critique [PDF]
, 2004 International audienceDans un article récent [11], Vishik montre que le système d'Euler bidimensionnel est globalement bien posé dans l'espace de Besov critique $B^2_{2,1}$. Nous montrons ici que le système de Navier-Stokes est globalement bien posé dans
Hmidi, Taoufik, Keraani, Sahbi
core +5 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Os Uniformes Militares Portugueses na Regeneração 1851-1892 [PDF]
, 1998 historiografia militar em Portugal careceu durante muitos anos da abordagem científica das características que envolvem o complexo mundo dos uniformes militares.
Veludo, Sérgio
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Uniformization of quasi-uniform spaces [PDF]
Bulletin of the Australian Mathematical Society, 1981 This paper considers the question of when a quasi-uniform space has a compatible uniform structure. Typical of the sufficient conditions provided is the result that a quasi-uniform space whose conjugate topology is compact and R0 is uniformizable.
Raghavan, T. G., Reilly, I. L.
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Versión 1993 de los requerimientos uniformes de publicación
Biomédica: revista del Instituto Nacional de Salud, 1994 A mediados de este ano, el lnternational Committee of Medical Journal Editors publicó una quinta versión de los requerimientos uniformes para someter manuscritos (1).
A. Loría, R. Lisker
doaj +1 more source
Elementos finitos híbridos com descontinuidades fortes incorporadas [PDF]
, 2006 A fim de tornar os elementos finitos híbridos aplicáveis no contexto da mecânica da fratura, apresenta-se uma técnica para incorporar fissuras no interior desses elementos que permite, de maneira simples e direta, extensões para a representação de ...
Manzoli, O., Shing, Benson
core
Kolmogorov condition near hyperbolic singularities of integrable Hamiltonian systems
, 2007 In this paper we show that, if an integrable Hamiltonian system admits a nondegenerate hyperbolic singularity then it will satisfy the Kolmogorov condegeneracy condition near that singularity (under a mild additional condition, which is trivial if the ...
B. Rink +11 more
core +5 more sources