Results 61 to 70 of about 217,028 (268)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Pesquisa Agropecuária Brasileira, 2004 O objetivo deste trabalho foi verificar a interferência de métodos de correção da produtividade de grãos de milho nos parâmetros adaptabilidade e estabilidade de cultivares. A correção da produtividade de grãos foi avaliada em 31 ensaios de competição de
Alberto Cargnelutti Filho +1 more
doaj +1 more source
Nanomaterials, 2023 The roll-to-roll (R2R) gravure process has the potential for manufacturing single-wall carbon nanotubes (SWCNT)-based thin film transistor (TFT) arrays on a flexible plastic substrate.
Yunhyok Choi +7 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Research on Load Distribution Uniformity of Clamping System of CT Injector Head
Shiyou jixie, 2020 There is no systematic study on the load distribution of the clamping blocks in the entire clamping area of the coiled tubing(CT)injector head. To address the problem, based on the basic theory of structural mechanics, a mechanical model of the injector ...
Hu Zhiqiang +5 more
doaj
Uniformization of quasi-uniform spaces [PDF]
Bulletin of the Australian Mathematical Society, 1981 This paper considers the question of when a quasi-uniform space has a compatible uniform structure. Typical of the sufficient conditions provided is the result that a quasi-uniform space whose conjugate topology is compact and R0 is uniformizable.
Raghavan, T. G., Reilly, I. L.
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Animals, 2021 The aim of this study was to assess the effects of energy-restricted feeding during rearing on the performance, uniformity, and development of layer breeders at the initiation of the laying period.
Jian Lu +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source