Results 101 to 110 of about 43,090 (300)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Australian Irrigation Conference and Exibition 2010: One Water Many Futures

, 2010
Field trials were conducted at three field sites in the Fassifern Valley to determine the effect of irrigation non-uniformity on carrot production. Catch cans were used to measure the distribution uniformity.
Koech, Richard, Raine, Steven R.
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Experimental Study on Ultra-Precision Turning of Freeform Optical Surfaces of Polymethyl Methacrylate with Nanometer Surface Roughness

Applied Sciences
The high performance of optical components is contingent upon the quality of their optical surfaces, thereby imposing elevated standards on the methodologies employed for their fabrication.
Xuchu Wang, Qingshun Bai, Liang Zhao, Kai Cheng   +3 more
doaj   +1 more source

Do Baseline P-Values Follow a Uniform Distribution in Randomised Trials?

PLoS ONE, 2013
The theory has been put forward that if a null hypothesis is true, P-values should follow a Uniform distribution. This can be used to check the validity of randomisation.The theory was tested by simulation for two sample t tests for data from a Normal distribution and a Lognormal distribution, for two sample t tests which are not independent, and for ...
openaire   +4 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Assessing application uniformity of a variable rate irrigation system in a windy location

, 2013
14 Págs., 6 Figs., 5 Tabls.Variable rate irrigation (VRI) systems are commercially available and can easily be retrofitted onto moving sprinkler systems. However, there are few reports on the application performance of such equipment.
O'Shaughnessy, Susan A., Howell, Terry A., Evett, Steven R., Urrego, Yenny F., Urrego Pereira, Yenny Fernanda, Colaizzi, Paul D., O\u27Shaughnessy, Susan A.   +6 more
core   +1 more source

Belt Sanding Robot for Large Convex Surfaces Featuring SEA Arms and an Active Re-Tensioner with PI Force Control

Machines
This study presents a belt sanding robot for large convex surfaces together with a proportional–integral force control method. Sanding belt tension strongly affects area coverage and spatial normal-force uniformity on large curved surfaces; existing ...
Hongjoo Jin, Chanhyuk Moon, Taegyun Kim, TaeWon Seo   +3 more
doaj   +1 more source