Results 51 to 60 of about 246 (149)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Body mass and sex estimation from lower carnassial tooth morphometry in the endangered Iberian wolf (Canis lupus signatus): An ecomorphological analysis of sexual size dimorphism

The Anatomical Record, EarlyView.
Abstract The Iberian wolf (Canis lupus signatus) is an endangered subspecies characterized by highly fragmented populations and increasing human–carnivore conflict across the Iberian Peninsula. Although body mass strongly influences predator–prey dynamics and ecological performance, quantitative assessments of sexual size dimorphism (SSD) and body mass
Leonardo Cotts, Eduardo Rossener, Ricardo Moratelli, Maria da Luz Mathias, Oscar Rocha‐Barbosa   +4 more
wiley   +1 more source

Electroconvulsive Therapy for Catatonia in Autistic and Non‐Autistic Patients: An Observational Study on Course, Efficacy, Aggression, and Self‐Injury Outcomes

Autism Research, EarlyView.
ABSTRACT Catatonia occurs disproportionately in autistic individuals and may respond to electroconvulsive therapy (ECT), yet prior reports suggest greater treatment burden in this population. We compared longitudinal ECT utilization, safety, and clinical outcomes between autistic and non‐autistic patients with catatonia.
Joshua Ryan Smith, Maria Bonnee, Sarah Marler, Seri Lim, D. Catherine Fuchs, Rafael Tamargo, Isaac Baldwin, Christopher Maley, Ashley VanHaverbeck, Courtney Hamilton, Timothy Adegoke, Haozheng Xu, Jinyuan Liu, Zachary J. Williams, Jo Ellen Wilson, James Luccarelli   +15 more
wiley   +1 more source

THE DECISION OF PROBLEMS WITH UNILATERAL CONSTRAINTS AND CULON'S FRICTION UNDER THE DYNAMIC LOAD

Structural Mechanics of Engineering Constructions and Buildings, 2011
The numerical approach to the decision of dynamic problems with unilateral constraints and Culon's friction is offered. The decision is formulated on the basis of step-by-step analysis (in time) method with use of frame contact finite elements.
A A Lukashevich
doaj  

Reciprocity on the Edge of Distance Paradox: How Sustainability Motives and Hypocrisy Shape Consumer Responses to Nearshoring

Business Strategy and the Environment, EarlyView.
ABSTRACT Despite growing interest in corporate relocation decisions and sustainability, the existing literature is limited in its consumer‐centric approach. Integrating social exchange theory and construal level theory, this research investigates how consumers perceive sustainability‐driven nearshoring motives (i.e., socio‐economic vs.
Cagla Dayangan, Nilay Bıçakcıoğlu‐Peynirci, Ozge Ozgen   +2 more
wiley   +1 more source

Digital Orientation and Green Practices in Chilean SMEs: Innovation as the Pathway to Competitive Performance

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how digital strategic orientation (DSO) and environmental practices (EP) interact to shape innovation and performance among Chilean SMEs. Using survey data from 271 firms (February–May 2022), we estimate a generalized structured component analysis (GSCA) model that accommodates a nonrecursive relationship between DSO and EP.
Constanza Caicha‐Caroca, Antonia Madrid‐Guijarro, Claudia Andrea Pezoa‐Fuentes   +2 more
wiley   +1 more source

EQUILIBRIUM STATE ANALYSIS OF A SYSTEM WITH UNILATERAL CONSTRAINTS BY FINITE DISPLACEMENTS

Structural Mechanics of Engineering Constructions and Buildings, 2010
A stability problem for an elastic structure subjected to conservative and active forces is considered. The structure has unilateral constraints and initial imperfections. An example of a system with two degrees of freedom shows that in general case, the
Yuri Borisovitch Goldshtein
doaj  

What Do We Know About Scope 3 Emissions in Small‐ and Medium‐Sized Enterprises? Mapping Current Knowledge and Advancing a Theory–Practice‐Oriented Framework

Business Strategy and the Environment, EarlyView.
ABSTRACT Although SMEs comprise over 90% of firms globally, research on their engagement with Scope 3 (value‐chain) greenhouse gas emissions remains limited. This PRISMA‐guided systematic review synthesises 49 SME‐relevant studies to develop a theory‐informed, practice‐oriented framework for more credible and sustained Scope 3 engagement.
Chidinma Uchendu, Okechukwu Okorie, Fatemeh Khosravi, Stuart Connop, Hebba Haddad, Mike Medas   +5 more
wiley   +1 more source

Nonlinear weakly elliptic 2X2 systems of variational inequalities with unilateral obstacle constraints

Electronic Journal of Differential Equations, 1997
We study $2 imes 2$ systems of variational inequalities which are only weakly elliptic; in particular, these systems are not necessarily monotone. The prototype differential operator is the (vector-valued) p-Laplacian. We prove, under certain conditions,
D. R. Adams, H. J. Nussenzveig Lopes
doaj  

Numerical modelling of sandwich panels with a non-continuous soft core

MATEC Web of Conferences, 2018
The paper presents the problem of static analysis of sandwich structures with a non-continuous soft core. In the numerical 3D FE models, the core is divided into separated parts. The contact between these parts has the form of unilateral constraints. The
Pozorska Jolanta
doaj   +1 more source