Results 61 to 70 of about 16,770 (217)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Effects of Wall‐to‐Floor Interactions on Seismic Response of Platform‐Type CLT Buildings

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Platform‐type cross‐laminated timber (CLT) buildings feature discontinuous wall segments supported by CLT floors. In practice, CLT floors are often treated as rigid diaphragm, yet the wall‐to‐floor interactions (WFIs) associated with flexibility of floors remain insufficiently investigated during seismic performance assessment.
Chaoyue Zhang, Yuxin Pan, Jiawei Chen, Huifeng Yang   +3 more
wiley   +1 more source

Research on Optimal Width of Coal Pillars in Both Sides of Abandoned Mining Areas and Tunnel Control Technology

Energy Science &Engineering, EarlyView.
This study primarily investigates the optimal width for coal pillar retention in both sides of the worked‐out face section. Taking the 42201 haulage roadway of the 42201 working face at Shengxin Coal Mine as the primary research target, it analyses the optimum width for coal pillar retention through theoretical calculations, numerical simulations, and ...
Shuaifeng Yin, Kanglei Han, En Wang, Yitao Yan, Xubo Zhao   +4 more
wiley   +1 more source

Laser neoureterocystostomy to treat ectopic ureters

Equine Veterinary Journal, EarlyView.
Abstract Background Ureteral ectopia is an uncommon but clinically important congenital abnormality in horses. If left untreated, it can lead to persistent dermatitis, urinary tract infections, and failure to thrive. Surgical correction is necessary, but traditional approaches have produced mixed results with high morbidity.
Caitlin Smith, Eric J. Parente
wiley   +1 more source

Geopolitics and global strategy: Making money under anarchy

Global Strategy Journal, EarlyView.
Abstract Research Summary Multinational firms conduct cross‐border trade and investment in a world of anarchy, where nation‐states must secure their survival in the absence of a world government. We develop a geopolitical‐economic order (GEO) framework to argue that the extent of geopolitical competition incentivizes states to create one of two types ...
Daniel J. Blake, Srividya Jandhyala, Quan Li   +2 more
wiley   +1 more source

Superior Labial Artery Mucosal Flap (SLAM) for Reconstruction of Major Lower Lip Mucosal Defects

Head &Neck, EarlyView.
ABSTRACT Background The superior labial artery mucosal (SLAM) flap is a versatile, pedicled axial flap ideally suited for mucosal lining in lower lip reconstruction. Methods This article details the surgical anatomy and technique of the SLAM flap, highlighting its role as a standalone liner or mucosal adjunct to microvascular free tissue transfer in ...
Nicholas Shannon, Takako Eva Yabe, Bruce Ashford   +2 more
wiley   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, EarlyView.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

Interplay Between Green Investment and Market Price Premia in Global Shipping

International Journal of Finance &Economics, EarlyView.
ABSTRACT Existing research emphasises that the driver of green investment is its future profitability. This paper shows that other investors' decisions also influence green investment. We take the example of scrubber installation in shipping, which is optional by regulation but has an established market for trading its underlying asset.
Yao Shi, Nikos C. Papapostolou, Malvina Marchese, Ioannis C. Moutzouris, Angelos Efstathiou   +4 more
wiley   +1 more source

Brexit and Its Impact on EU Financial Markets

International Journal of Finance &Economics, EarlyView.
ABSTRACT We investigate the impact of Brexit on volatility spillovers across the EU countries. We introduce a Brexit intensity measure that assigns an intensity score reflective of the financial markets' reaction to the events that occurred as Brexit negotiations began to unfold.
Marwan Izzeldin, Gulnur Muradoglu, Vasileios Pappas, Sheeja Sivaprasad   +3 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source