Results 111 to 120 of about 101,596 (292)

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Graves' Disease With Unilateral Involvement: A Rare Entity [Tek Taraflı Tutulum Görülen Graves Hastalı?ı: Nadir Bir Vaka]

, 2011
Graves' disease usually affects both lobes of the gland, thus, unilateral Graves' hyperthyroidism has been reported very rarely. Here, we report a case of Graves' disease presenting with unilateral involvement of the thyroid gland. Thyroid
Gönülalan G., Çakir M.
core  

Bone Marrow Biopsy for the Staging of Non-Hodgkin's Lymphoma: Bilateral or Unilateral Trephine Biopsy?

, 1995
Aim The occurrence of unilateral involvement in bilateral bone marrow trephine biopsies in non-Hodgkin's lymphomas (NHL) at disease onset (10-20% of cases) has been reported since the early 70s.
Antonio Tocci, Edmondo Cassi, Patrizia Marinoni, Luigi Montalbetti, Alberto De Paoli, Sergio Fava, Gabriele Sangalli, Paolo Declich, Patrizia Sciuccati, Marco Luoni, Agnese Assi, Anna Tosi   +11 more
core   +1 more source

Unilateral retinitis pigmentosa: A proposal of genetic pathogenic mechanisms

, 2012
PURPOSE. To investigate and integrate anatomic and physiologic findings from a group of patients who present retinitis pigmentosa affecting just one eye and use this information to propose mechanisms of disease pathogenesis. METHODS.
Duncker T, PEIRETTI, ENRICO, Tsang S.H., Brodie SE, Marsiglia M   +4 more
core   +2 more sources

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

A case of pemphigus vegetans with unilateral axillary involvement Tek tarafli aksiller bölgenin tutulduǧu pemfigus vejetans olgusu

, 2010
Pemphigus vegetans is the rarest form of pemphigus that is an autoimmune disease. It occurs in 1-2% of all patients with pemphigus. The disease is classified as the Neumann and Hallopeau types according to the clinical picture and course.
BAYRAMGÜRLER, DİLEK, Demirci, Kamile, Erçin, Cengiz, ŞİKAR AKTÜRK, AYSUN, KIRAN, REBİAY   +4 more
core  

Nonsyndromic multisuture craniosynostosis with unilateral coronal and lambdoid suture involvement

Interdisciplinary Neurosurgery
Background: Craniosynostosis results from the premature fusion of cranial sutures and represents a severe congenital craniofacial disorder. It may occur as part of a recognized genetic syndrome or as an isolated condition.
Vázquez Flores Jesús de Marco, Ramos Fraga Bernardo, Ferreira Ascencio Frida Leslie, López Hernández Paul André   +3 more
doaj   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Unilateral Exophthalmos due to Lymphomatous Involvement

Internal Medicine, 2018
Yasuda, Miho, Iwamuro, Masaya, Kimura, Kosuke, Otsuka, Fumio   +3 more
openaire   +3 more sources

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source