Results 91 to 100 of about 3,878,773 (285)

On an initial-boundary value problem for the nonlinear Schrödinger equation

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1979
We study an initial-boundary value problem for the nonlinear Schrödinger equation, a simple mathematical model for the interaction between electromagnetic waves and a plasma layer.
Herbert Gajewski
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Unique Existence Theorem of Solution of Almost Periodic Differential Equations on Time Scales

open access: yesDiscrete Dynamics in Nature and Society, 2012
By using the theory of calculus on time scales and M-matrix theory, the unique existence theorem of solution of almost periodic differential equations on almost periodic time scales is established. The result can be used to a large of dynamic systems.
Meng Hu, Lili Wang
doaj   +1 more source

Ordinary differential equations and descriptive set theory: uniqueness and globality of solutions of Cauchy problems in one dimension

open access: yes, 1996
We study some natural sets arising in the theory of ordinary differential equations in one variable from the point of view of descriptive set theory and in particular classify them within the Borel hierarchy.
Andretta, Alessandro, Marcone, Alberto
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Evidence for Many Unique Solution Structures for Chymotrypsin Inhibitor 2: A Thermodynamic Perspective Derived from vT-ESI-IMS-MS Measurements. [PDF]

open access: yesJ Am Chem Soc, 2020
Raab SA   +9 more
europepmc   +1 more source

On the Relationship Between Determinate and MSV Solutions in Linear RE Models [PDF]

open access: yes
This paper considers the possibility that, in linear rational expectations (RE) models, all determinate (uniquely non-explosive) solutions coincide with the minimum state variable (MSV) solution, which is unique by construction.
Bennett McCallum
core  

EXISTENCE AND UNIQUENESS OF CHAIN LADDER SOLUTIONS

open access: yesASTIN Bulletin, 2015
AbstractThe cross-classified chain ladder has a number of versions, depending on the distribution to which observations are subject. The simplest case is that of Poisson distributed observations, and then maximum likelihood estimates of parameters are explicit.
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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