Results 81 to 90 of about 3,878,773 (285)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Kardiyovasküler Tıp E Dergisi/E Journal of Cardiovascular MedicineThe extracardiac Fontan procedure is the final common pathway for palliation of patients with univentricular physiology. The procedure is typically performed on cardiopulmonary bypass with or without fenestration using an adequate-sized ...
Ali H. Mashadi, Sameh M. Said
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Electronic Journal of Differential Equations, 2006 We show the exact asymptotic behaviour near the boundary for the classical solution to the Dirichler problem $$ -Delta =k(x)g(u)+lambda |abla u|^q, quad u>0,; xin Omega,quad uig|_{partial{Omega}}=0, $$ where $Omega$ is a bounded domain with smooth ...
Zhijun Zhang
doaj
Infinite-dimensional stochastic differential equations arising from Airy random point fields
, 2016 We identify infinite-dimensional stochastic differential equations (ISDEs) describing the stochastic dynamics related to Airy$_{\beta } $ random point fields with $ \beta =1,2,4 $. We prove the existence of unique strong solutions of these ISDEs. When $ \
Osada, Hirofumi, Tanemura, Hideki
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Uniqueness of Slowly Oscillating Periodic Solutions
Journal of Mathematical Analysis and Applications, 1993 For the nonlinear delay differential equation \(\dot x(t)=\gamma x(t)+\gamma f(x(t-1))\), \(\gamma\in\mathbb{R}^ +\), the uniqueness of the solution is studied assuming that \(f\) is an odd function and \(f(A)=-A\) for some positive \(A\). The slowly oscillating periodic \((S)\) solutions are also discussed.
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A survey on fractal fractional nonlinear Kawahara equation theoretical and computational analysis
Scientific ReportsWith the use of the Caputo, Caputo-Fabrizio (CF), and Atangana-Baleanu-Caputo (ABC) fractal fractional differential operators, this study offers a theoretical and computational approach to solving the Kawahara problem by merging Laplace transform and ...
Laila A. Al-Essa, Mati ur Rahman
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source