Results 71 to 80 of about 3,878,773 (285)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Revising claims and resisting ultimatums in bargaining problems. [PDF]
We propose a mechanism which implements a unique solution to the bargaining problem with two players in subgame-perfect equilibrium. Players start by making claims and accept a compromise only if they cannot gain by pursuing their claim in an ultimatum ...
Spinnewijn, Johannes, Spinnewyn, Frans
core +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Electronic Journal of Differential Equations, 2007 Let $mathbb{T}$ be a periodic time scale. We use a fixed point theorem due to Krasnosel'skii to show that the nonlinear neutral dynamic equation with delay $$ x^{Delta}(t) = -a(t)x^{sigma}(t) + left(Q(t,x(t), x(t-g(t)))) ight)^{Delta} + Gig(t,x(t), x(t-g(
Eric R. Kaufmann, Youssef N. Raffoul
doaj
The Existence of a Unique Solution of the Hyperbolic Functional Differential Equation
Demonstratio Mathematica, 2014 We consider the Z. Szmydt problem for the hyperbolic functional differential equation. We prove a theorem on existence of a unique classical solution and the Carathéodory solution of the hyperbolic equation.
Karpowicz Adrian
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The exact asymptotic behaviour of the unique solution to a singular Dirichlet problem
Boundary Value Problems, 2006 By Karamata regular variation theory, we show the existence and exact asymptotic behaviour of the unique classical solution near the boundary to a singular Dirichlet problem , , , , where is a bounded domain with smooth boundary in , , , for each and
Yu Jianning, Zhang Zhijun
doaj +2 more sources
The Unique Positive Solution for Singular Hadamard Fractional Boundary Value Problems
Journal of Function Spaces, 2019 In this paper, we investigate singular Hadamard fractional boundary value problems. The existence and uniqueness of the exact iterative solution are established only by using an iterative algorithm.
Jinxiu Mao, Zengqin Zhao, Chenguang Wang
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source