Results 71 to 80 of about 1,145 (256)
Journal of Function Spaces, 2017 Sufficient conditions are found for the correct and unique solvability of a class of third-order parabolic operator differential equations, whose principal parts have multiple characteristics, in a Sobolev-type space with exponential weight.
Araz R. Aliev +2 more
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Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2016 Настоящая статья является примером применения методов построения решения, интегральных и дифференциальных уравнений. Здесь рассматривается уравнение параболо-гиперболического типа вида ?/?x + ?/?y (Lu) = 0 в пятиугольной области.
Mamazhonov, M. +2 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Unique solvability of a crack problem with Signorini-type and Tresca friction conditions in a linearized elastodynamic body. [PDF]
Philos Trans A Math Phys Eng Sci, 2022 Kashiwabara T, Itou H.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On problems with displacement in boundary conditions for hyperbolic equation
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016 We consider three problems for hyperbolic equation on a plane in the characteristic domain. In these problems at least one of the conditions of the Goursat problem is replaced by nonlocal condition on the relevant characteristic. Non-local conditions are
Elena A Utkina
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Mathematical Modelling and Analysis, 2008 General conditions are obtained for the unique solvability of a non‐local boundary value problem for systems of linear functional differential equations.
András Rontó +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source