Results 121 to 130 of about 3,546,472 (360)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Value distribution of difference polynomials of meromorphic functions

open access: yesElectronic Journal of Differential Equations, 2013
In this article, we study the value distribution of difference polynomials of meromorphic functions, and obtain some results which can be viewed as discrete analogues of the results given by Yi and Yang [11].
Yong Liu, Xiaoguang Qi, Hongxun Yi
doaj  

Relatively unique, or uniquely relative

open access: yes, 2019
The relativistic transformation in hyperbolic form is uniquely symmetric, invertible, and unimodular; it also uniquely preserves quadratic differences.
openaire   +1 more source

A Unique Case. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1902
Pittsburg, Pa., June 14, 1902. To the Editor: —I have thought the following case of sufficient interest to report. My friend, Dr. R. J. Phillips of this city, attended a woman in her second confinement yesterday. There was a twin birth (boys), both children well delevoped except that each one had a harelip and one has five fingers on one hand and ...
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

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